K L Brain
Overview
Explore the profile of K L Brain including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
259
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Recent Articles
1.
Botting K, Skeffington K, Niu Y, Allison B, Brain K, Itani N, et al.
Sci Adv
. 2020 Sep;
6(34):eabb1929.
PMID: 32875110
The prenatal origins of heart disease in offspring have been established. However, research in species with developmental milestones comparable to humans is lacking, preventing translation of this knowledge to clinical...
2.
Allison B, Brain K, Niu Y, Kane A, Herrera E, Thakor A, et al.
J Physiol
. 2016 Mar;
594(5):1247-64.
PMID: 26926316
Although the fetal cardiovascular defence to acute hypoxia and the physiology underlying it have been established for decades, how the fetal cardiovascular system responds to chronic hypoxia has been comparatively...
3.
Kobayter S, Young J, Brain K
Br J Pharmacol
. 2011 Jun;
165(2):401-13.
PMID: 21671904
Background And Purpose: The acute effects of PGE(2) on bladder smooth muscle and nerves were examined to determine the origin of PGE(2)-induced spontaneous rhythmic contractions. Experimental Approach: Contraction studies, confocal...
4.
Brading A, Brain K
Handb Exp Pharmacol
. 2011 Feb;
(202):375-93.
PMID: 21290236
The membrane potential fulfils an important role in initiating smooth muscle contraction, through its depolarization and the subsequent influx of Ca(2+) through voltage-gated Ca(2+) channels. Changes in membrane potential can...
5.
Brain K
Exp Physiol
. 2008 Sep;
94(1):25-30.
PMID: 18805863
Determining whether ATP and noradrenaline are released from the same vesicle at mature autonomic neuroeffector junctions is challenging because of the difficulty of simultaneously detecting the packeted release of these...
6.
Brain K, Cunnane T
Br J Pharmacol
. 2007 Dec;
153(4):831-9.
PMID: 18071295
Background And Purpose: The antidysrhythmic bretylium is useful experimentally because it selectively abolishes neurotransmitter release from sympathetic peripheral nerve terminals. Its mechanism of action seemed settled, but recent results from...
7.
Young J, Brain K, Cunnane T
Neuroscience
. 2007 Jul;
148(1):82-91.
PMID: 17629625
Simultaneous electrophysiology and confocal microscopy were used to investigate purinergic neurotransmission at single smooth muscle cells (SMCs) in mouse isolated vas deferens, and to explore the relationship between two high-resolution...
8.
Williams D, Brain K, Cunnane T
Br J Pharmacol
. 2007 Feb;
150(7):906-12.
PMID: 17325648
Background And Purpose: Nicotinic agonists increase sympathetic field-stimulus-evoked contraction of the rodent vas deferens, presumably by increasing evoked neurotransmitter release. This presumption was tested in two species. Experimental Approach: The...
9.
Young J, Brain K, Cunnane T
Neuroscience
. 2007 Jan;
145(1):153-61.
PMID: 17208381
The skewed amplitude distribution of spontaneous excitatory junction potentials (sEJPs) in the mouse vas deferens and other electrically-coupled smooth muscle syncytia has been attributed to electrically-attenuated depolarizations resulting from the...
10.
Jackson V, Trout S, Brain K, Cunnane T
J Physiol
. 2001 Nov;
537(Pt 1):3-16.
PMID: 11711556
1. Action potential-evoked Ca(2+) transients in postganglionic sympathetic axon bundles in mouse vas deferens have been characterized using confocal microscopy and Ca(2+) imaging. 2. Axonal Ca(2+) transients were tetrodotoxin sensitive....