Alpha 2.0
Login Register
» Authors » K Kirito

K Kirito

Explore the profile of K Kirito including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 23
Citations 196
Followers 0
Related Specialties
Hematology
Biochemistry
Oncology
Top 10 Co-Authors
N Komatsu
Y Miura
M Uchida
K Ozawa
M Nakamura
Y Furukawa
M Saito
T Izumi
Y Kashii
N Chiba
Published In
Blood
Rinsho Ketsueki
J Biol Chem
Exp Hematol
Oncogene
Affiliations
Soon will be listed here.
Recent Articles
1.
Spectrum of clinical and genetic features of patients with inherited platelet disorder with suspected predisposition to hematological malignancies: a nationwide survey in Japan
Yoshimi A, Toya T, Nannya Y, Takaoka K, Kirito K, Ito E, et al.
Ann Oncol . 2016 Feb; 27(5):887-95. PMID: 26884589
Background: Inherited thrombocytopenia (IT) contains several forms of familial thrombocytopenia and some of them have propensity to hematological malignancies. The etiological and genetic features of this heterogeneous syndrome have not...
2.
Divergent cytotoxic effects of PKC412 in combination with conventional antileukemic agents in FLT3 mutation-positive versus -negative leukemia cell lines
Furukawa Y, Vu H, Akutsu M, Odgerel T, Izumi T, Tsunoda S, et al.
Leukemia . 2007 Mar; 21(5):1005-14. PMID: 17330105
FMS-like tyrosine kinase-3 (FLT3) is a new therapeutic target for acute myelocytic leukemia (AML), because FLT3 mutations are the most common genetic alterations in AML and are directly related to...
3.
Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells
Ohmine K, Ota J, Ueda M, Ueno S, Yoshida K, Yamashita Y, et al.
Oncogene . 2002 Jan; 20(57):8249-57. PMID: 11781839
Chronic myeloid leukemia (CML) is characterized by the clonal expansion of hematopoietic stem cells (HSCs). Without effective treatment, individuals in the indolent, chronic phase (CP) of CML undergo blast crisis...
4.
Identification of myelodysplastic syndrome-specific genes by DNA microarray analysis with purified hematopoietic stem cell fraction
Miyazato A, Ueno S, Ohmine K, Ueda M, Yoshida K, Yamashita Y, et al.
Blood . 2001 Jul; 98(2):422-7. PMID: 11435312
Myelodysplastic syndrome (MDS) is a slowly progressing hematologic malignancy associated with a poor outcome. Despite the relatively high incidence of MDS in the elderly, differentiation of MDS from de novo...
5.
A functional role of mitogen-activated protein kinases, erk1 and erk2, in the differentiation of a human leukemia cell line, UT-7/GM: a possible key factor for cell fate determination toward erythroid and megakaryocytic lineages
Uchida M, Kirito K, Shimizu R, Miura Y, Ozawa K, Komatsu N
Int J Hematol . 2001 May; 73(1):78-83. PMID: 11372759
The mitogen-activated protein (MAP) kinase cascade is a key regulator of mammalian cell proliferation and differentiation. In this study, we examined the roles of 2 members of the MAP kinase...
6.
Forkhead family transcription factor FKHRL1 is expressed in human megakaryocytes. Regulation of cell cycling as a downstream molecule of thrombopoietin signaling
Tanaka M, Kirito K, Kashii Y, Uchida M, Watanabe T, Endo H, et al.
J Biol Chem . 2001 Mar; 276(18):15082-9. PMID: 11278373
FKHRL1, a member of the Forkhead transcription factor family, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt. This molecule is a mammalian homolog of DAF-16, which plays an important...
7.
Sialyl-Tn- and neuron-specific enolase-positive minimally differentiated erythroleukemia
Muroi K, Tarumoto T, Akioka T, Kirito K, Nagai T, Izumi T, et al.
Intern Med . 2000 Oct; 39(10):843-6. PMID: 11030212
Flow cytometric, immunochemical and molecular studies were performed on leukemic blasts from a patient with minimally differentiated erythroleukemia (AML-M6v). The blasts expressed CD36 and CD71 but not lymphoid antigens, myeloid...
8.
A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction
Kashii Y, Uchida M, Kirito K, Tanaka M, Nishijima K, Toshima M, et al.
Blood . 2000 Jul; 96(3):941-9. PMID: 10910908
The phosphatidylinositol 3-kinase (PI3K) signaling pathway is important for the regulation of a number of cellular responses. Serine/threonine kinase Akt (protein kinase B; PKB) is downstream of PI3K and activated...
9.
GATA-1 and erythropoietin receptor genes are highly expressed in erythroleukemia
Komatsu N, Kirito K, Izumi T, Eguchi M, Miura Y
Exp Hematol . 1998 Nov; 26(12):1148-54. PMID: 9808054
We examined expression of the erythroid-associated genes GATA-1 and erythropoietin receptor (EPOR) in primary leukemia using the reverse transcriptase-polymerase chain reaction (RT-PCR). GATA-1 and EPOR mRNAs were detectable in all...
10.
Thrombopoietin supports in vitro erythroid differentiation via its specific receptor c-Mpl in a human leukemia cell line
Yamada M, Komatsu N, Kirito K, Kashii Y, Tomizuka H, Okada K, et al.
Cell Growth Differ . 1998 Jul; 9(6):487-96. PMID: 9663467
Thrombopoietin (TPO) acts on megakaryopoiesis and erythropoiesis in vitro and in vivo. We isolated a novel subline, UT-7/GMT, from the human leukemia cell line UT-7/GM (N. Komatsu, et al., Blood,...