K K McKee
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Explore the profile of K K McKee including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
1286
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Recent Articles
1.
Palucki B, Feighner S, Pong S, McKee K, Hreniuk D, Tan C, et al.
Bioorg Med Chem Lett
. 2001 Jul;
11(14):1955-7.
PMID: 11459669
A series of small molecules derived from MK-0677, a potent synthetic GHS, mimicking the N-terminal Gly-Ser-O-(n-octanoyl)-L-Ser-Phe segment of ghrelin was synthesized and tested in a binding and in a functional...
2.
Smith R, Leonard R, Bailey A, Palyha O, Feighner S, Tan C, et al.
Endocrine
. 2001 Apr;
14(1):9-14.
PMID: 11322507
We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of...
3.
Bednarek M, Feighner S, Pong S, McKee K, Hreniuk D, Silva M, et al.
J Med Chem
. 2000 Nov;
43(23):4370-6.
PMID: 11087562
The recently discovered growth hormone secretagogue, ghrelin, is a potent agonist at the human growth hormone secretagogue receptor 1a (hGHSR1a). To elucidate structural features of this peptide necessary for efficient...
4.
Howard A, Wang R, Pong S, Mellin T, Strack A, Guan X, et al.
Nature
. 2000 Jul;
406(6791):70-4.
PMID: 10894543
Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species. It is widely distributed in...
5.
Palyha O, Feighner S, Tan C, McKee K, Hreniuk D, Gao Y, et al.
Mol Endocrinol
. 2000 Jan;
14(1):160-9.
PMID: 10628755
Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH-secretagogue receptor (GHS-R). The GHS-R is rhodopsin like, but does...
6.
Smith R, Palyha O, Feighner S, Tan C, McKee K, Hreniuk D, et al.
Horm Res
. 1999 Dec;
51 Suppl 3:1-8.
PMID: 10592437
A series of structurally diverse growth hormone (GH) releasing substances have been synthesized that are distinct from the naturally occurring GH releasing hormone (GHRH). These synthetic molecules range from the...
7.
Feighner S, Tan C, McKee K, Palyha O, Hreniuk D, Pong S, et al.
Science
. 1999 Jun;
284(5423):2184-8.
PMID: 10381885
Motilin is a 22-amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by stimulating interdigestive antrum and duodenal contractions. A...
8.
Tan C, McKee K, Weinberg D, MacNeil T, Palyha O, Feighner S, et al.
FEBS Lett
. 1999 Jun;
451(2):137-41.
PMID: 10371153
The primary hormonal regulator of pigmentation is melanocyte stimulating hormone derived from proopiomelanocortin by proteolytic processing. The melanocortin-1 receptor serves a key role in the regulation of pigmentation. We describe...
9.
Tan C, McKee K, Liu Q, Palyha O, Feighner S, Hreniuk D, et al.
Genomics
. 1998 Oct;
52(2):223-9.
PMID: 9782091
Growth hormone secretagogues (GHS) are a group of synthetic peptide and nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a...
10.
McKee K, Tan C, Palyha O, Liu J, Feighner S, Hreniuk D, et al.
Genomics
. 1998 Jan;
46(3):426-34.
PMID: 9441746
The recent cloning of a growth hormone secretagogue receptor (GHS-R) from human pituitary gland and brain identified a third G protein-coupled receptor (GPC-R) involved in the control of growth hormone...