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K K Caldwell

Explore the profile of K K Caldwell including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 20
Citations 276
Followers 0
Related Specialties
Biochemistry
Cell Biology
Science
Top 10 Co-Authors
P W MAJERUS
V S Bansal
D M Cooper
C A Mitchell
T W Cunningham
D L Lips
W Schlegel
B S Wilson
R A Harris
D D Savage
Published In
J Biol Chem
Proc Natl Acad Sci U S A
Mol Biol Cell
Cell Calcium
Ann N Y Acad Sci
Affiliations
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Recent Articles
1.
Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: identification of a myotubularin-related protein lacking catalytic activity
Nandurkar H, Caldwell K, Whisstock J, Layton M, Gaudet E, Norris F, et al.
Proc Natl Acad Sci U S A . 2001 Aug; 98(17):9499-504. PMID: 11504939
The D3-phosphoinositides act as second messengers by recruiting, and thereby activating, diverse signaling proteins. We have previously described the purification of a rat phosphatidylinositol 3-phosphate [PtdIns(3)P] 3-phosphatase, comprising a heterodimer...
2.
Fear conditioning-induced alterations of phospholipase C-beta1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex
Weeber E, Savage D, Sutherland R, Caldwell K
Neurobiol Learn Mem . 2001 Aug; 76(2):151-82. PMID: 11502147
We investigated the effects of one-trial fear conditioning on phospholipase C-beta1a catalytic activity and protein level in hippocampal formation and medial frontal cortex of untreated control rats and rats prenatally...
3.
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol
Munday A, Norris F, Caldwell K, Brown S, MAJERUS P, Mitchell C
Proc Natl Acad Sci U S A . 1999 Mar; 96(7):3640-5. PMID: 10097090
Inositol polyphosphate 4-phosphatase (4-phosphatase) is an enzyme that catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2]. In human platelets the formation of this phosphatidylinositol, by the actions...
4.
Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line
Tannheimer S, Ethier S, Caldwell K, Burchiel S
Carcinogenesis . 1998 Jul; 19(7):1291-7. PMID: 9683191
Previous studies in this laboratory have shown that polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (BaP), and certain halogenated aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), modulate receptor signaling pathways in human...
5.
Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells
Barker S, Caldwell K, Pfeiffer J, Wilson B
Mol Biol Cell . 1998 Apr; 9(2):483-96. PMID: 9450969
In RBL-2H3 tumor mast cells, cross-linking the high affinity IgE receptor (FcepsilonRI) with antigen activates cytosolic tyrosine kinases and stimulates Ins(1,4,5)P3 production. Using immune complex phospholipase assays, we show that...
6.
Effects of prenatal ethanol exposure on phospholipase C-beta 1 and phospholipase A2 in hippocampus and medial frontal cortex of adult rat offspring
Allan A, Weeber E, Savage D, Caldwell K
Alcohol Clin Exp Res . 1997 Dec; 21(8):1534-41. PMID: 9394128
Previous studies in our laboratory using a rat model of fetal alcohol exposure (FAE) suggest that FAE-induced behavioral deficits are, in part, linked to neurochemical and electrophysiological deficits in long-term...
7.
Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking
Barker S, Caldwell K, Hall A, Martinez A, Pfeiffer J, Oliver J, et al.
Mol Biol Cell . 1995 Sep; 6(9):1145-58. PMID: 8534912
We have investigated the effects of wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase), on antigen-mediated signaling in the RBL-2H3 mast cell model. In RBL-2H3 cells, the cross-linking of high...
8.
The effects of Ca2+ and calmodulin on adenylyl cyclase activity in plasma membranes derived from neural and non-neural cells
Caldwell K, Boyajian C, Cooper D
Cell Calcium . 1992 Feb; 13(2):107-21. PMID: 1633609
The regulation of adenylyl cyclase activity by varying concentrations of Ca2+ was examined in plasma membrane preparations derived from a number of neural and non-neural cells. Enzyme activity in neural...
9.
Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate
Walsh J, Caldwell K, MAJERUS P
Proc Natl Acad Sci U S A . 1991 Oct; 88(20):9184-7. PMID: 1656463
We have synthesized phosphatidylinositol 3-phosphate from phosphatidylinositol 4-phosphate by using diisopropylcarbodiimide to promote migration of the 4-phosphate via a cyclic phosphodiester intermediate. The product was isolated by a thin-layer chromatographic...
10.
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate
Caldwell K, Lips D, Bansal V, MAJERUS P
J Biol Chem . 1991 Sep; 266(27):18378-86. PMID: 1655747
Inositol-polyphosphate 3-phosphatase catalyzes the hydrolysis of the 3-position phosphate bond of inositol 1,3-bisphosphate (Ins(1,3)P2) to form inositol 1-monophosphate and inorganic phosphate (Bansal, V.S., Inhorn, R.C., and Majerus, P.W. (1987) J....