K J Scheidegger
Overview
Explore the profile of K J Scheidegger including associated specialties, affiliations and a list of published articles.
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10
Citations
155
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Recent Articles
1.
Anwar A, Zahid A, Scheidegger K, Brink M, Delafontaine P
Circulation
. 2002 Mar;
105(10):1220-5.
PMID: 11889017
Background: Inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), interleukin 1beta (IL-1beta), IL-6, and interferon gamma (IFN-gamma) may change coronary plaque integrity by altering vascular smooth muscle cell (VSMC) survival...
2.
Okura Y, Brink M, Itabe H, Scheidegger K, Kalangos A, Delafontaine P
Circulation
. 2000 Nov;
102(22):2680-6.
PMID: 11094032
Background: Cytotoxic oxidized LDL (oxLDL) has been shown to promote apoptosis in cultured vascular smooth muscle cells (VSMCs). We investigated the localization of oxLDL and its association with apoptosis and...
3.
Scheidegger K, Cenni B, Picard D, Delafontaine P
J Biol Chem
. 2000 Sep;
275(49):38921-8.
PMID: 10982795
Insulin-like growth factor (IGF-1) is a potent mitogen for vascular smooth muscle cells. Both IGF-1 and its receptor have been shown to be highly expressed in atherosclerotic lesions. Here we...
4.
Scheidegger K, James R, Delafontaine P
J Biol Chem
. 2000 Jun;
275(35):26864-9.
PMID: 10862615
Low density lipoproteins (LDLs) play an important role in the pathogenesis of atherosclerosis. LDL has been shown to be mitogenic and proapoptotic for vascular smooth muscle cells. However, the mechanisms...
5.
Du J, Peng T, Scheidegger K, Delafontaine P
Arterioscler Thromb Vasc Biol
. 1999 Sep;
19(9):2119-26.
PMID: 10479653
We have recently shown that angiotensin II activation of insulin-like growth factor 1 receptor (IGF-1R) transcription is a critical requirement for angiotensin-stimulated vascular smooth muscle cell growth; therefore, we examined...
6.
Scheidegger K, Du J, Delafontaine P
J Biol Chem
. 1999 Jan;
274(6):3522-30.
PMID: 9920898
Angiotensin II (Ang II) and basic fibroblast growth factor (bFGF) are important modulators of cell growth under physiological and pathophysiological conditions. We and others have previously shown that these growth...
7.
Scheidegger K, Leenders P, Daemen M, Smits J, Wood J
J Hypertens
. 1998 Feb;
15(12 Pt 1):1455-62.
PMID: 9431852
Objective: To investigate the effects of long-term treatment with blockers of the renin-angiotensin system on capillarization and growth of fibers in ischemic hind-limb muscles and in muscles under normal growth...
8.
Scheidegger K, Wood J
J Vasc Res
. 1998 Jan;
34(6):436-46.
PMID: 9425996
The aim of this study was to determine the effects of angiotensin II (Ang II) on the vascular wall, that are independent of its effects on systemic blood pressure. Ang...
9.
Scheidegger K, Butler S, Witztum J
J Biol Chem
. 1997 Aug;
272(34):21609-15.
PMID: 9261183
The molecular and cellular mechanisms by which hypertension enhances atherosclerosis are poorly understood. Angiotensin II (Ang II) has been implicated in the regulation of cellular lipoxygenases (LO), which are thought...
10.
Scheidegger K, Wood J, van Essen H, Struijker-Boudier H
J Pharmacol Exp Ther
. 1996 Sep;
278(3):1276-81.
PMID: 8819512
Changes in microcirculation play an important role in the pathogenesis and maintenance of hypertension. The changes can be due to an alteration in vessel diameter or in the number of...