Justin Courcelle
Overview
Explore the profile of Justin Courcelle including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
735
Followers
0
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Recent Articles
1.
Worley T, Asal A, Cooper L, Courcelle C, Courcelle J
Mutat Res
. 2025 Feb;
830:111898.
PMID: 39903998
Crosslinking agents, such as psoralen and UVA radiation, can be effectively used as antimicrobials and for treating several dysplastic conditions in humans, including some cancers. Yet, both cancer cells and...
2.
Worley T, Asal A, Cooper L, Courcelle C, Courcelle J
bioRxiv
. 2024 Dec;
PMID: 39677732
Crosslinking agents, such as psoralen and UVA radiation, can be effectively used as antimicrobials and for treating several dysplastic conditions in humans, including some cancers. Yet, both cancer cells and...
3.
Wang N, Courcelle E, Coltman S, Spolek R, Courcelle J, Courcelle C
Biometals
. 2023 Jul;
36(6):1361-1376.
PMID: 37493920
Following hydrogen peroxide treatment, ferrous iron (Fe) is oxidized to its ferric form (Fe), stripping it from and inactivating iron-containing proteins. Many mononuclear iron enzymes can be remetallated by manganese...
4.
Worley T, Weber E, Acott J, Shimpi R, Cole J, Courcelle C, et al.
J Bacteriol
. 2023 May;
205(6):e0012623.
PMID: 37249472
DNA interstrand cross-links, such as those formed by psoralen-UVA irradiation, are highly toxic lesions in both humans and bacteria, with a single lesion being lethal in Escherichia coli. Despite the...
5.
Hamilton N, Jehru A, Samples W, Wendel B, Mokhtari P, Courcelle C, et al.
J Biol Chem
. 2023 Feb;
299(3):103013.
PMID: 36781123
Accurately completing DNA replication when two forks converge is essential to genomic stability. The RecBCD helicase-nuclease complex plays a central role in completion by promoting resection and joining of the...
6.
Courcelle J, Worley T, Courcelle C
Genes (Basel)
. 2022 Mar;
13(3).
PMID: 35327990
Recombination mediator proteins have come into focus as promising targets for cancer therapy, with synthetic lethal approaches now clinically validated by the efficacy of PARP inhibitors in treating BRCA2 cancers...
7.
Hoff C, Schmidt S, Hackert B, Worley T, Courcelle J, Courcelle C
G3 (Bethesda)
. 2021 Feb;
11(4).
PMID: 33591320
UV irradiation induces pyrimidine dimers that block polymerases and disrupt the replisome. Restoring replication depends on the recF pathway proteins which process and maintain the replication fork DNA to allow...
8.
Wendel B, Hollingsworth S, Courcelle C, Courcelle J
Genes Cells
. 2020 Dec;
26(2):94-108.
PMID: 33382157
Replication initiation, elongation and completion are tightly coordinated to ensure that all sequences replicate precisely once each generation. UV-induced DNA damage disrupts replication and delays elongation, which may compromise this...
9.
Hutfilz C, Wang N, Hoff C, Lee J, Hackert B, Courcelle J, et al.
J Bacteriol
. 2019 Oct;
201(24).
PMID: 31570529
Divalent metals such as iron and manganese play an important role in the cellular response to oxidative challenges and are required as cofactors by many enzymes. However, how these metals...
10.
Hamilton N, Wendel B, Weber E, Courcelle C, Courcelle J
Mol Microbiol
. 2019 Mar;
111(6):1638-1651.
PMID: 30883946
The accurate completion of DNA replication on the chromosome requires RecBCD and structure specific SbcCD and ExoI nucleases. However, the substrates and mechanism by which this reaction occurs remains unknown....