Justin C Deme
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Explore the profile of Justin C Deme including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
699
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Recent Articles
1.
Stagno J, Deme J, Dwivedi V, Lee Y, Lee H, Yu P, et al.
Nucleic Acids Res
. 2025 Mar;
53(5).
PMID: 40071935
Synthetic RNA devices are engineered to control gene expression and offer great potential in both biotechnology and clinical applications. Here, we present multidisciplinary structural and biochemical data for a tetracycline...
2.
Mariano G, Deme J, Readshaw J, Grobbelaar M, Keenan M, El-Masri Y, et al.
Nat Commun
. 2025 Mar;
16(1):2344.
PMID: 40057510
Bacteria have evolved an extraordinary diversity of defense systems against bacteriophage (phage) predation. However, the molecular mechanisms underlying these anti-phage systems often remain elusive. Here, we provide mechanistic and structural...
3.
Parker J, Deme J, Lichtinger S, Kuteyi G, Biggin P, Lea S, et al.
Nat Commun
. 2024 Oct;
15(1):8755.
PMID: 39384780
The uptake and elimination of beta-lactam antibiotics in the human body are facilitated by the proton-coupled peptide transporters PepT1 (SLC15A1) and PepT2 (SLC15A2). The mechanism by which SLC15 family transporters...
4.
Johnson S, Deme J, Furlong E, Caesar J, Chevance F, Hughes K, et al.
Res Sq
. 2024 Aug;
PMID: 39108497
The bacterial flagellum is a macromolecular protein complex that harvests energy from ion-flow across the inner membrane to power bacterial swimming in viscous fluids via rotation of the flagellar filament....
5.
Lauber F, Deme J, Liu X, Kjaer A, Miller H, Alcock F, et al.
Nat Microbiol
. 2024 Mar;
9(4):1089-1102.
PMID: 38538833
Secretion systems are protein export machines that enable bacteria to exploit their environment through the release of protein effectors. The Type 9 Secretion System (T9SS) is responsible for protein export...
6.
Johnson S, Deme J, Furlong E, Caesar J, Chevance F, Hughes K, et al.
Nat Microbiol
. 2024 Mar;
9(5):1282-1292.
PMID: 38459206
The bacterial flagellum is a macromolecular protein complex that harvests energy from uni-directional ion flow across the inner membrane to power bacterial swimming via rotation of the flagellar filament. Rotation...
7.
Ding J, Deme J, Stagno J, Yu P, Lea S, Wang Y
Nucleic Acids Res
. 2023 Aug;
51(18):9952-9960.
PMID: 37534568
RNA conformational heterogeneity often hampers its high-resolution structure determination, especially for large and flexible RNAs devoid of stabilizing proteins or ligands. The adenosylcobalamin riboswitch exhibits heterogeneous conformations under 1 mM...
8.
Levdansky Y, Raisch T, Deme J, Pekovic F, Elmlund H, Lea S, et al.
Commun Biol
. 2023 Jul;
6(1):739.
PMID: 37460791
NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains...
9.
Alteen M, Deme J, Alvarez C, Loppnau P, Hutchinson A, Seitova A, et al.
Structure
. 2023 Jun;
31(9):1121-1131.e6.
PMID: 37390814
The huntingtin (HTT) protein plays critical roles in numerous cellular pathways by functioning as a scaffold for its many interaction partners and HTT knock out is embryonic lethal. Interrogation of...
10.
Hennell James R, Deme J, Hunter A, Berks B, Lea S
mBio
. 2022 Apr;
13(3):e0026722.
PMID: 35446127
Gliding motility using cell surface adhesins, and export of proteins by the type IX secretion system (T9SS) are two phylum-specific features of the Bacteroidetes. Both of these processes are energized...