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» Authors » Jurgen Zezula

Jurgen Zezula

Explore the profile of Jurgen Zezula including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 147
Followers 0
Related Specialties
Biochemistry
Biology
Cell Biology
Top 10 Co-Authors
Michael Freissmuth
Ingrid Gsandtner
Simon Keuerleber
Christoforos Charalambous
Patrick Thurner
Oliver Kudlacek
Christian Nanoff
Daniel Choquet
Simon Weissmann
Manuela Baccarini
Published In
J Biol Chem
J Cell Biol
Development
Affiliations
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Recent Articles
1.
A two-state model for the diffusion of the A2A adenosine receptor in hippocampal neurons: agonist-induced switch to slow mobility is modified by synapse-associated protein 102 (SAP102)
Thurner P, Gsandtner I, Kudlacek O, Choquet D, Nanoff C, Freissmuth M, et al.
J Biol Chem . 2014 Feb; 289(13):9263-74. PMID: 24509856
The A2A receptor is a class A/rhodopsin-like G protein-coupled receptor. Coupling to its cognate protein, Gs, occurs via restricted collision coupling and is contingent on the presence of cholesterol. Agonist...
2.
A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog
Hagelkruys A, Lagger S, Krahmer J, Leopoldi A, Artaker M, Pusch O, et al.
Development . 2014 Jan; 141(3):604-616. PMID: 24449838
The histone deacetylases HDAC1 and HDAC2 are crucial regulators of chromatin structure and gene expression, thereby controlling important developmental processes. In the mouse brain, HDAC1 and HDAC2 exhibit different developmental...
3.
Reengineering the collision coupling and diffusion mode of the A2A-adenosine receptor: palmitoylation in helix 8 relieves confinement
Keuerleber S, Thurner P, Gruber C, Zezula J, Freissmuth M
J Biol Chem . 2012 Oct; 287(50):42104-18. PMID: 23071116
The A(2A)-adenosine receptor undergoes restricted collision coupling with its cognate G protein G(s) and lacks a palmitoylation site at the end of helix 8 in its intracellular C terminus. We...
4.
Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development
Galabova-Kovacs G, Catalanotti F, Matzen D, Reyes G, Zezula J, Herbst R, et al.
J Cell Biol . 2008 Mar; 180(5):947-55. PMID: 18332218
Mutations in the extracellular signal-regulated kinase (ERK) pathway, particularly in the mitogen-activated protein kinase/ERK kinase (MEK) activator B-Raf, are associated with human tumorigenesis and genetic disorders. Hence, B-Raf is a...
5.
Restricted collision coupling of the A2A receptor revisited: evidence for physical separation of two signaling cascades
Charalambous C, Gsandtner I, Keuerleber S, Milan-Lobo L, Kudlacek O, Freissmuth M, et al.
J Biol Chem . 2008 Jan; 283(14):9276-88. PMID: 18218631
The A(2A)-adenosine receptor is a prototypical G(s) protein-coupled receptor but stimulates MAPK/ERK in a G(s)-independent way. The A(2A) receptor has long been known to undergo restricted collision coupling with G(s);...
6.
Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway
Gsandtner I, Charalambous C, Stefan E, Ogris E, Freissmuth M, Zezula J
J Biol Chem . 2005 Jul; 280(36):31898-905. PMID: 16027149
The A2A adenosine receptor is a prototypical G(s)-coupled receptor, but it also signals, e.g. to mitogen-activated protein (MAP) kinase, via a pathway that is independent of heterotrimeric G proteins. Truncation...