Jurgen Mattern
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Explore the profile of Jurgen Mattern including associated specialties, affiliations and a list of published articles.
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22
Citations
663
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Recent Articles
1.
Efferth T, Koomagi R, Mattern J, Volm M
Cancer Genomics Proteomics
. 2019 Aug;
1(3):249-254.
PMID: 31394660
Epidemiological studies have established a causal relationship between cigarette smoking and respiratory tract cancer. The knowledge about the interaction of tobacco constituents with cellular systems is, however, still incomplete. Therefore,...
2.
Isayev O, Rausch V, Bauer N, Liu L, Fan P, Zhang Y, et al.
Oncotarget
. 2014 Jul;
5(13):5177-89.
PMID: 25015789
According to the cancer stem cell (CSC) hypothesis, the aggressive growth and early metastasis of pancreatic ductal adenocarcinoma (PDA) is due to the activity of CSCs, which are not targeted...
3.
Liu L, Salnikov A, Bauer N, Aleksandrowicz E, Labsch S, Nwaeburu C, et al.
Int J Cancer
. 2014 Mar;
134(10):2489-503.
PMID: 24615157
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies characterized by an intense tumor stroma with hypoperfused regions, a significant inflammatory response and pronounced therapy resistance. New therapeutic...
4.
Salnikov A, Liu L, Platen M, Gladkich J, Salnikova O, Ryschich E, et al.
PLoS One
. 2012 Oct;
7(9):e46391.
PMID: 23050024
Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de novo, enhances migration of existing CSCs...
5.
Zhou W, Kallifatidis G, Baumann B, Rausch V, Mattern J, Gladkich J, et al.
Int J Oncol
. 2010 Jul;
37(3):551-61.
PMID: 20664924
According to the cancer stem cell hypothesis the aggressive growth and early metastasis of pancreatic cancer may arise through dysregulation of self-renewal of stem cells in the tissue. Since recent...
6.
Rausch V, Liu L, Kallifatidis G, Baumann B, Mattern J, Gladkich J, et al.
Cancer Res
. 2010 Jun;
70(12):5004-13.
PMID: 20530687
Recent evidence suggests that pancreatic cancer and other solid tumors contain a subset of tumorigenic cells capable of extensive self-renewal that contribute to metastasis and treatment resistance. Sorafenib (SO) is...
7.
Salnikov A, Gladkich J, Moldenhauer G, Volm M, Mattern J, Herr I
Int J Cancer
. 2009 Aug;
126(4):950-8.
PMID: 19676044
Despite advances in anticancer treatment, lung cancer still has poor prognosis. Recently, a cancer stem cell (CSC) hypothesis has emerged describing a small subset of tumor cells with stem cell...
8.
Herr I, Buchler M, Mattern J
Results Probl Cell Differ
. 2009 Jan;
49:191-218.
PMID: 19132324
More than a quarter of a century ago, the phenomenon of glucocorticoid-induced apoptosis in the majority of hematological cells was first recognized. More recently, glucocorticoid-induced antiapoptotic signaling associated with apoptosis...
9.
Efferth T, Konkimalla V, Wang Y, Sauerbrey A, Meinhardt S, Zintl F, et al.
Clin Cancer Res
. 2008 Apr;
14(8):2405-12.
PMID: 18413831
Purpose: Drug resistance is a major obstacle in cancer chemotherapy. Although the statistical probability of therapeutic success is known for larger patient groups from clinical therapy trials, it is difficult...
10.
Mattern J, Buchler M, Herr I
Cancer Biol Ther
. 2007 Dec;
6(9):1345-54.
PMID: 18087223
Glucocorticoids have been widely used as cotreatment for patients with cancer due to potent pro-apoptotic properties in lymphoid cells, reduction of nausea and diminishing acute toxicity on normal tissue. There...