Jure Leskovec
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Explore the profile of Jure Leskovec including associated specialties, affiliations and a list of published articles.
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84
Citations
4259
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Recent Articles
1.
Chevalley M, Roohani Y, Mehrjou A, Leskovec J, Schwab P
Commun Biol
. 2025 Mar;
8(1):412.
PMID: 40069299
Mapping biological mechanisms in cellular systems is a fundamental step in early-stage drug discovery that serves to generate hypotheses on what disease-relevant molecular targets may effectively be modulated by pharmacological...
2.
Huang K, Zeng T, Koc S, Pettet A, Zhou J, Jain M, et al.
medRxiv
. 2024 Dec;
PMID: 39677475
Genome-wide association studies (GWASs) have identified tens of thousands of disease associated variants and provided critical insights into developing effective treatments. However, limited sample sizes have hindered the discovery of...
3.
Bunne C, Roohani Y, Rosen Y, Gupta A, Zhang X, Roed M, et al.
Cell
. 2024 Dec;
187(25):7045-7063.
PMID: 39672099
Cells are essential to understanding health and disease, yet traditional models fall short of modeling and simulating their function and behavior. Advances in AI and omics offer groundbreaking opportunities to...
4.
Bunne C, Roohani Y, Rosen Y, Gupta A, Zhang X, Roed M, et al.
ArXiv
. 2024 Oct;
PMID: 39398201
The cell is arguably the most fundamental unit of life and is central to understanding biology. Accurate modeling of cells is important for this understanding as well as for determining...
5.
Huang K, Chandak P, Wang Q, Havaldar S, Vaid A, Leskovec J, et al.
Nat Med
. 2024 Sep;
30(12):3601-3613.
PMID: 39322717
Drug repurposing-identifying new therapeutic uses for approved drugs-is often a serendipitous and opportunistic endeavour to expand the use of drugs for new diseases. The clinical utility of drug-repurposing artificial intelligence...
6.
Riesel E, Mackey T, Nilforoshan H, Xu M, Badding C, Altman A, et al.
J Am Chem Soc
. 2024 Sep;
146(44):30340-30348.
PMID: 39298266
Powder X-ray diffraction (PXRD) is a cornerstone technique in materials characterization. However, complete structure determination from PXRD patterns alone remains time-consuming and is often intractable, especially for novel materials. Current...
7.
Huang K, Chandak P, Wang Q, Havaldar S, Vaid A, Leskovec J, et al.
medRxiv
. 2024 Aug;
PMID: 39148855
Drug repurposing - identifying new therapeutic uses for approved drugs - is often serendipitous and opportunistic, expanding the use of drugs for new diseases. The clinical utility of drug repurposing...
8.
Brbic M, Yasunaga M, Agarwal P, Leskovec J
medRxiv
. 2024 Mar;
PMID: 38496488
Optimal treatments depend on numerous factors such as drug chemical properties, disease biology, and patient characteristics to which the treatment is applied. To realize the promise of AI in healthcare,...
9.
Rosen Y, Brbic M, Roohani Y, Swanson K, Li Z, Leskovec J
Nat Methods
. 2024 Feb;
21(8):1492-1500.
PMID: 38366243
Analysis of single-cell datasets generated from diverse organisms offers unprecedented opportunities to unravel fundamental evolutionary processes of conservation and diversification of cell types. However, interspecies genomic differences limit the joint...
10.
Nilforoshan H, Looi W, Pierson E, Villanueva B, Fishman N, Chen Y, et al.
Nature
. 2023 Nov;
624(7992):586-592.
PMID: 38030732
A long-standing expectation is that large, dense and cosmopolitan areas support socioeconomic mixing and exposure among diverse individuals. Assessing this hypothesis has been difficult because previous measures of socioeconomic mixing...