Juraj Michalik
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Explore the profile of Juraj Michalik including associated specialties, affiliations and a list of published articles.
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10
Citations
780
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Recent Articles
1.
Michalik J, Niederlova V, Stepanek O
Front Immunol
. 2024 Oct;
15:1446931.
PMID: 39445006
Single-cell RNA sequencing (scRNA-seq) methods are widely used in life sciences, including immunology. Typical scRNA-seq analysis pipelines quantify the abundance of particular transcripts without accounting for alternative splicing. However, a...
2.
Janusova S, Paprckova D, Michalik J, Uleri V, Drobek A, Salyova E, et al.
EMBO Rep
. 2024 Jun;
25(8):3456-3485.
PMID: 38877170
T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by...
3.
Paprckova D, Salyova E, Michalik J, Stepanek O
Curr Opin Immunol
. 2023 Mar;
82:102299.
PMID: 36913776
Antigen-induced memory T cells undergo counterintuitive activation in an antigen-independent manner, which is called bystander response. Although it is well documented that memory CD8 T cells produce IFNγ and upregulate...
4.
Tsyklauri O, Chadimova T, Niederlova V, Kovarova J, Michalik J, Malatova I, et al.
Elife
. 2023 Jan;
12.
PMID: 36705564
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity. In this study, we...
5.
Paprckova D, Niederlova V, Moudra A, Drobek A, Pribikova M, Janusova S, et al.
Front Immunol
. 2022 Oct;
13:1009198.
PMID: 36275704
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important...
6.
Moudra A, Niederlova V, Novotny J, Schmiedova L, Kubovciak J, Matejkova T, et al.
J Immunol
. 2021 Apr;
206(9):2109-2121.
PMID: 33858960
Ag-inexperienced memory-like T (AIMT) cells are functionally unique T cells, representing one of the two largest subsets of murine CD8 T cells. However, differences between laboratory inbred strains, insufficient data...
7.
Flissi A, Ricart E, Campart C, Chevalier M, Dufresne Y, Michalik J, et al.
Nucleic Acids Res
. 2019 Nov;
48(D1):D465-D469.
PMID: 31691799
Norine, the unique resource dedicated to nonribosomal peptides (NRPs), is now updated with a new pipeline to automate massive sourcing and enhance annotation. External databases are mined to extract NRPs...
8.
Couvin D, Bernheim A, Toffano-Nioche C, Touchon M, Michalik J, Neron B, et al.
Nucleic Acids Res
. 2018 May;
46(W1):W246-W251.
PMID: 29790974
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous mobile genetic elements, such as phages or plasmids. CRISPRCasFinder...
9.
Michalik J, Touzet H, Ponty Y
Bioinformatics
. 2017 Sep;
33(14):i283-i292.
PMID: 28882001
Motivation: Kinetics is key to understand many phenomena involving RNAs, such as co-transcriptional folding and riboswitches. Exact out-of-equilibrium studies induce extreme computational demands, leading state-of-the-art methods to rely on approximated...
10.
Flissi A, Dufresne Y, Michalik J, Tonon L, Janot S, Noe L, et al.
Nucleic Acids Res
. 2015 Nov;
44(D1):D1113-8.
PMID: 26527733
Since its creation in 2006, Norine remains the unique knowledgebase dedicated to non-ribosomal peptides (NRPs). These secondary metabolites, produced by bacteria and fungi, harbor diverse interesting biological activities (such as...