Radislav Sedlacek
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Explore the profile of Radislav Sedlacek including associated specialties, affiliations and a list of published articles.
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168
Citations
2186
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Recent Articles
1.
Gambini F, Arbon D, Nickl P, Zatecka V, Fedosieieva O, Labaj J, et al.
Mamm Genome
. 2025 Feb;
PMID: 39985688
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection is not limited to the respiratory tract as receptors, including the angiotensin-converting enzyme 2 (ACE2), are expressed across many tissues. This study...
2.
Weiner C, Hecht I, Lindovsky J, Palkova M, Krupkova M, Kasparek P, et al.
Clin Exp Ophthalmol
. 2025 Feb;
PMID: 39956648
Background: This study investigates the role of the SLC38A8 gene. SLC38A8 facilitates glutamine influx, which converts to glutamate in the visual pathway. Mutations in SLC38A8 are associated with FHONDA syndrome,...
3.
Basova P, Minarik L, Magalhaes-Novais S, Balounova J, Zemanova Z, Aghova T, et al.
Front Oncol
. 2025 Jan;
14():1414950.
PMID: 39839764
Introduction: Progressing myelodysplastic syndrome (MDS) into acute myeloid leukemia (AML) is an indication for hypomethylating therapy (HMA, 5-Azacytidine (AZA)) and a BCL2 inhibitor (Venetoclax, VEN) for intensive chemotherapy ineligible patients....
4.
Vo P, Imai-Leonard D, Yang B, Briere A, Shao A, Casanova M, et al.
BMC Genomics
. 2025 Jan;
26(1):48.
PMID: 39833678
Purpose: Corneal dysmorphologies (CDs) are typically classified as either regressive degenerative corneal dystrophies (CDtrs) or defective growth and differentiation-driven corneal dysplasias (CDyps). Both eye disorders have multifactorial etiologies. While previous...
5.
Zbikowski A, Kowalczyk T, Kasparek P, Prohazka J, Sedlacek R, Ciborowski M, et al.
Mamm Genome
. 2024 Dec;
PMID: 39738582
Phosphofurin acidic cluster sorting protein 2 (PACS2) plays a vital role in maintaining cellular homeostasis by regulating protein trafficking between cellular membranes. This function impacts crucial processes like apoptosis, mitochondria-endoplasmic...
6.
Ujevic A, Knizkova D, Synackova A, Pribikova M, Trivic T, Dalinskaya A, et al.
Nat Commun
. 2024 Nov;
15(1):10013.
PMID: 39562788
The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced cell death by regulating the activation of...
7.
Rico-Llanos G, Spoutil F, Blahova E, Koudelka A, Prochazkova M, Czyrek A, et al.
J Bone Miner Res
. 2024 Oct;
39(12):1783-1792.
PMID: 39423254
Achondroplasia is the most common form of human dwarfism caused by mutations in the FGFR3 receptor tyrosine kinase. Current therapy begins at 2 years of age and improves longitudinal growth...
8.
Elrick H, Peterson K, Willis B, Lanza D, Acar E, Ryder E, et al.
Sci Rep
. 2024 Sep;
14(1):22626.
PMID: 39349521
The International Mouse Phenotyping Consortium (IMPC) systematically produces and phenotypes mouse lines with presumptive null mutations to provide insight into gene function. The IMPC now uses the programmable RNA-guided nuclease...
9.
Nedomova M, Haberecht-Muller S, Moller S, Venz S, Prochazkova M, Prochazka J, et al.
iScience
. 2024 Sep;
27(10):110893.
PMID: 39328932
DDI2 is an aspartic protease that cleaves polyubiquitinated substrates. Upon proteotoxic stress, DDI2 activates the transcription factor TCF11/NRF1 (NFE2L1), crucial for maintaining proteostasis in mammalian cells, enabling the expression of...
10.
Nickl P, Jenickova I, Elias J, Kasparek P, Barinka C, Kopkanova J, et al.
Sci Rep
. 2024 Aug;
14(1):20160.
PMID: 39215103
Site-specific recombinases (SSRs) are critical for achieving precise spatiotemporal control of engineered alleles. These enzymes play a key role in facilitating the deletion or inversion of loci flanked by recombination...