Junxiang Wan
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Explore the profile of Junxiang Wan including associated specialties, affiliations and a list of published articles.
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63
Citations
2458
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Recent Articles
1.
Kumagai H, Kim S, Miller B, Zempo H, Tanisawa K, Natsume T, et al.
iScience
. 2024 Nov;
27(11):111212.
PMID: 39559755
MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to CK2 and activates it in cell-free...
2.
Kumagai H, Kim S, Miller B, Natsume T, Wan J, Kumagai M, et al.
Am J Physiol Endocrinol Metab
. 2024 Jan;
326(3):E207-E214.
PMID: 38170165
Mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), a mitochondrial microprotein, has been described as a novel regulator of glucose and lipid metabolism. In addition to its...
3.
Min J, Rouanet J, Martini A, Nashiro K, Yoo H, Porat S, et al.
Sci Rep
. 2023 Mar;
13(1):3967.
PMID: 36894565
Slow paced breathing via heart rate variability (HRV) biofeedback stimulates vagus-nerve pathways that counter noradrenergic stress and arousal pathways that can influence production and clearance of Alzheimer's disease (AD)-related proteins....
4.
Miller B, Kim S, Mehta H, Cao K, Kumagai H, Thumaty N, et al.
Mol Psychiatry
. 2023 Jan;
28(4):1827.
PMID: 36658336
No abstract available.
5.
Miller B, Kim S, Mehta H, Cao K, Kumagai H, Thumaty N, et al.
Mol Psychiatry
. 2022 Sep;
28(4):1813-1826.
PMID: 36127429
Mitochondrial DNA variants have previously associated with disease, but the underlying mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 associated with Alzheimer's disease (AD), neuroimaging, and...
6.
Ramirez-Torres A, Reagan A, Howard L, Wiggins E, Vidal A, Wan J, et al.
Prostate
. 2022 Jul;
82(13):1248-1257.
PMID: 35789022
Introduction: The mitochondrial genome has small open reading frames (sORF) which produce measurable mitochondrial-derived peptides (MDPs), including humanin, SHLP2, and MOTS-c. Previously, among men undergoing prostate biopsy, we found higher...
7.
Nashine S, Cohen P, Wan J, Kenney M
Aging (Albany NY)
. 2022 May;
14(10):4247-4269.
PMID: 35576057
Inflammation plays a crucial role in the etiology and pathogenesis of AMD (Age-related Macular Degeneration). Humanin G (HNG) is a Mitochondrial Derived Peptide (MDP) that is cytoprotective in AMD and...
8.
Wang Y, Qiao L, Yang J, Li X, Duan Y, Liu J, et al.
Cancer Commun (Lond)
. 2021 Nov;
41(12):1373-1386.
PMID: 34738326
Background: To date, there is no approved blood-based biomarker for breast cancer detection. Herein, we aimed to assess semaphorin 4C (SEMA4C), a pivotal protein involved in breast cancer progression, as...
9.
Wang Y, Liu J, Li J, Li H, Li X, Qiao L, et al.
Clin Transl Med
. 2021 Aug;
11(8):e480.
PMID: 34459126
No abstract available.
10.
Sequeira I, Woodhead J, Chan A, DSouza R, Wan J, Hollingsworth K, et al.
Biochim Biophys Acta Gen Subj
. 2021 Aug;
1865(11):129991.
PMID: 34419510
Mitochondrial-derived peptides (MDPs) are encoded by the mitochondrial genome and hypothesised to form part of a retrograde signalling network that modulates adaptive responses to metabolic stress. To understand how metabolic...