Junghae Suh
Overview
Explore the profile of Junghae Suh including associated specialties, affiliations and a list of published articles.
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49
Citations
941
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Recent Articles
1.
Nagy M, Price S, Wang K, Gill S, Ren E, Jayne L, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2418024121.
PMID: 39602276
Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN-related disorders, there are no...
2.
Nagy M, Price S, Wang K, Gill S, Ren E, McElrath L, et al.
bioRxiv
. 2024 Sep;
PMID: 39282347
Spinal motor neuron (MN) dysfunction is the cause of a number of clinically significant movement disorders. Despite the recent approval of gene therapeutics targeting these MN-related disorders, there are no...
3.
Tien E, Grubor B, Kirkland M, Chan S, van der Munnik N, Xu W, et al.
Toxicol Pathol
. 2024 Feb;
52(1):35-54.
PMID: 38385340
Recombinant adeno-associated virus (AAV)-mediated degeneration of sensory neurons in the dorsal root ganglia (DRG) and trigeminal ganglia (TG) has been observed in non-human primates (NHPs) following intravenous (IV) and intrathecal...
4.
Brooks P, Miller T, Revah F, Suh J, Garrison B, Starke L, et al.
Nat Rev Drug Discov
. 2024 Feb;
23(3):157-158.
PMID: 38321319
No abstract available.
5.
Chen M, Kim B, Jarvis M, Fleury S, Deng S, Nouraein S, et al.
Gene Ther
. 2022 Nov;
30(5):429-442.
PMID: 36372846
Adeno-associated virus (AAV) vector-based gene therapies can be applied to a wide range of diseases. AAV expression can last for months to years, but vector re-administration may be necessary to...
6.
Chen M, Chen W, Tong J, Ho M, Suh J
Virology
. 2021 Sep;
563:107-115.
PMID: 34509702
Adeno-associated virus (AAV) is a promising gene therapy vector, but questions remain regarding mechanisms of basic viral functions. We previously showed that a serine/threonine (S/T) triplet motif and its flanking...
7.
Butler S, Date K, Okumura T, Lueck C, Ghosh B, Maitra A, et al.
Gene Ther
. 2021 May;
29(3-4):138-146.
PMID: 33958732
Adeno-associated virus' (AAV) relatively simple structure makes it accommodating for engineering into controllable delivery platforms. Cancer, such as pancreatic ductal adenocarcinoma (PDAC), are often characterized by upregulation of membrane-bound proteins,...
8.
Frustration and Direct-Coupling Analyses to Predict Formation and Function of Adeno-Associated Virus
Thadani N, Zhou Q, Reyes Gamas K, Butler S, Bueno C, Schafer N, et al.
Biophys J
. 2020 Dec;
120(3):489-503.
PMID: 33359833
Adeno-associated virus (AAV) is a promising gene therapy vector because of its efficient gene delivery and relatively mild immunogenicity. To improve delivery target specificity, researchers use combinatorial and rational library...
9.
Karawdeniya B, Bandara Y, Khan A, Chen W, Vu H, Morshed A, et al.
Nanoscale
. 2020 Nov;
12(46):23721-23731.
PMID: 33231239
Solid-state nanopore (SSN)-based analytical methods have found abundant use in genomics and proteomics with fledgling contributions to virology - a clinically critical field with emphasis on both infectious and designer-drug...
10.
Brun M, Song K, Kang B, Lueck C, Chen W, Thatcher K, et al.
J Control Release
. 2020 Nov;
328:834-845.
PMID: 33157191
Adeno-associated virus (AAV) is a promising vector for gene therapy, but its broad tropism can be detrimental if the transgene being delivered is harmful when expressed ubiquitously in the body,...