Jun Ninomiya-Tsuji
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Explore the profile of Jun Ninomiya-Tsuji including associated specialties, affiliations and a list of published articles.
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58
Citations
3228
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Recent Articles
1.
Tsuji Y, Ninomiya-Tsuji J, Shen M, DiFrancesco B
Redox Biol
. 2024 Dec;
79():103444.
PMID: 39674082
Despite the vital role of iron and vulnerability of iron metabolism in disease states, it remains largely unknown whether chemicals interacting with cellular proteins are responsible for perturbation of iron...
2.
Sai K, Nakanishi A, Scofield K, Tokarz D, Linder K, Cohen T, et al.
J Cell Sci
. 2023 Mar;
136(6).
PMID: 36912451
Neuroinflammation is causally associated with Alzheimer's disease (AD) pathology. Reactive glia cells secrete various neurotoxic factors that impair neuronal homeostasis eventually leading to neuronal loss. Although the glial activation mechanism...
3.
Lopez-Perez W, Sai K, Sakamachi Y, Parsons C, Kathariou S, Ninomiya-Tsuji J
Proc Natl Acad Sci U S A
. 2021 Jun;
118(25).
PMID: 34161265
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), known as TAK1, is an intracellular signaling intermediate of inflammatory responses. However, a series of mouse gene deletion analyses have revealed that ablation...
4.
Sai K, Parsons C, House J, Kathariou S, Ninomiya-Tsuji J
J Cell Biol
. 2019 Apr;
218(6):1994-2005.
PMID: 30975711
RIPK3, a key mediator of necroptosis, has been implicated in the host defense against viral infection primary in immune cells. However, gene expression analysis revealed that RIPK3 is abundantly expressed...
5.
Sung Hsieh H, Agarwal S, Cholok D, Loder S, Kaneko K, Huber A, et al.
Stem Cells
. 2019 Feb;
37(6):766-778.
PMID: 30786091
Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of transforming growth factor-β activated kinase 1 (TAK1) signaling reduces...
6.
Liu X, Hayano S, Pan H, Inagaki M, Ninomiya-Tsuji J, Sun H, et al.
Genesis
. 2018 Feb;
56(3):e23093.
PMID: 29411501
BMP signaling plays a critical role in craniofacial development. Augmentation of BMPR1A signaling through neural crest-specific expression of constitutively active Bmpr1a (caBmpr1a) results in craniofacial deformities in mice. To investigate...
7.
Mihaly S, Sakamachi Y, Ninomiya-Tsuji J, Morioka S
Sci Rep
. 2017 Sep;
7(1):10695.
PMID: 28878387
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
8.
Mihaly S, Sakamachi Y, Ninomiya-Tsuji J, Morioka S
Sci Rep
. 2017 Jun;
7(1):2918.
PMID: 28592892
Programmed cell death (PCD) occurs in several forms including apoptosis and necroptosis. Apoptosis is executed by the activation of caspases, while necroptosis is dependent on the receptor interacting protein kinase...
9.
Sakamachi Y, Morioka S, Mihaly S, Takaesu G, Foley J, Fessler M, et al.
Cell Death Dis
. 2017 Feb;
8(2):e2598.
PMID: 28182011
Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during...
10.
Hashimoto K, Simmons A, Kajino-Sakamoto R, Tsuji Y, Ninomiya-Tsuji J
Antioxid Redox Signal
. 2016 Jun;
25(17):953-964.
PMID: 27245349
Aims: Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is the master transcriptional regulator of antioxidant gene expression. On increased oxidative stress, an adaptor for Nrf2 degradation, Kelch-like ECH-associated protein...