Jun-Jie Gogo Liu
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Explore the profile of Jun-Jie Gogo Liu including associated specialties, affiliations and a list of published articles.
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15
Citations
122
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Recent Articles
1.
Li D, Zhang S, Lin S, Xing W, Yang Y, Zhu F, et al.
Nat Commun
. 2024 Dec;
15(1):10727.
PMID: 39737904
Exceptionally diverse type V CRISPR-Cas systems provide numerous RNA-guided nucleases as powerful tools for DNA manipulation. Two known Cas12e nucleases, DpbCas12e and PlmCas12e, are both effective in genome editing. However,...
2.
Hu X, Zhang X, Sun W, Liu C, Deng P, Cao Y, et al.
Nucleic Acids Res
. 2024 Aug;
52(17):10464-10489.
PMID: 39189466
Tandem repeat proteins (TRPs) are widely distributed and bind to a wide variety of ligands. DNA-binding TRPs such as zinc finger (ZNF) and transcription activator-like effector (TALE) play important roles...
3.
Chen Y, Evavold C, Mann M, Davenport E, McFall-Ngai M, Bienko M, et al.
Cell
. 2024 Aug;
187(17):4433-4438.
PMID: 39178826
We asked researchers from a range of disciplines across biology, engineering, and medicine to describe a current technological need. The goal is to provide a sample of the various technological...
4.
Xing W, Li D, Wang W, Liu J, Chen C
Nucleic Acids Res
. 2024 Jul;
52(15):9014-9027.
PMID: 38994558
CasX (also known as Cas12e), a Class 2 CRISPR-Cas system, shows promise in genome editing due to its smaller size compared to the widely used Cas9 and Cas12a. Although the...
5.
Zhang S, Sun A, Qian J, Lin S, Xing W, Yang Y, et al.
Nature
. 2024 May;
630(8016):484-492.
PMID: 38811729
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA. As part of the ongoing struggle between phages and...
6.
Liu Z, Zhang S, Zhu H, Chen Z, Yang Y, Li L, et al.
Science
. 2024 Feb;
383(6682):eadh4859.
PMID: 38301022
Ribozymes are catalytic RNAs with diverse functions including self-splicing and polymerization. This work aims to discover natural ribozymes that behave as hydrolytic and sequence-specific DNA endonucleases, which could be repurposed...
7.
Deng P, Tan S, Yang Q, Fu L, Wu Y, Zhu H, et al.
Cell
. 2023 Jun;
186(13):2865-2879.e20.
PMID: 37301196
Retroelements are the widespread jumping elements considered as major drivers for genome evolution, which can also be repurposed as gene-editing tools. Here, we determine the cryo-EM structures of eukaryotic R2...
8.
Hu Z, Sun A, Yang J, Naz G, Sun G, Li Z, et al.
Chem Sci
. 2023 Jun;
14(22):5945-5955.
PMID: 37293662
Chemical modifications of CRISPR-Cas nucleases help decrease off-target editing and expand the biomedical applications of CRISPR-based gene manipulation tools. Here, we found that epigenetic modifications of guide RNA, such as...
9.
Sun R, Zhao Y, Wang W, Liu J, Chen C
Chem Sci
. 2023 Apr;
14(14):3839-3851.
PMID: 37035707
Cas12a is one of the most commonly used Cas proteins for genome editing and gene regulation. The first key step for Cas12a to fulfill its function is to search for...
10.
Sun A, Li C, Chen Z, Zhang S, Li D, Yang Y, et al.
Cell Res
. 2023 Jan;
33(3):229-244.
PMID: 36650285
CRISPR-Cas modules serve as the adaptive nucleic acid immune systems for prokaryotes, and provide versatile tools for nucleic acid manipulation in various organisms. Here, we discovered a new miniature type...