Jun-Ichi Hayashi
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Explore the profile of Jun-Ichi Hayashi including associated specialties, affiliations and a list of published articles.
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128
Citations
2247
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Recent Articles
1.
Tani H, Ishikawa K, Tamashiro H, Ogasawara E, Yasukawa T, Matsuda S, et al.
Nucleic Acids Res
. 2022 Aug;
50(16):9382-9396.
PMID: 35998911
Mitochondrial tRNAs are indispensable for the intra-mitochondrial translation of genes related to respiratory subunits, and mutations in mitochondrial tRNA genes have been identified in various disease patients. However, the molecular...
2.
Kaneko S, Usui J, Hagiwara M, Shimizu T, Ishii R, Takahashi-Kobayashi M, et al.
Exp Anim
. 2021 Jul;
71(1):14-21.
PMID: 34321368
Focal segmental glomerulosclerosis (FSGS) is a major renal complication of human mitochondrial disease. However, its pathogenesis has not been fully explained. In this study, we focused on the glomerular injury...
3.
Kishita Y, Ishikawa K, Nakada K, Hayashi J, Fushimi T, Shimura M, et al.
Sci Rep
. 2021 May;
11(1):11123.
PMID: 34045482
Leigh syndrome (LS) is an early-onset progressive neurodegenerative disorder associated with mitochondrial deficiency. m.14597A>G (p.Ile26Thr) in the MT-ND6 gene was reported to cause Leber's hereditary optic neuropathy (LHON) or dementia/dysarthria....
4.
Murakami A, Hayashi J, Igawa K, Tsutsumi M, Tomooka K, Nagai H, et al.
Chirality
. 2020 Jul;
32(9):1152-1159.
PMID: 32602569
During the course of our chemical analysis of the hydrophilic fractions from marine cyanobacterium Moorena producens, we have isolated natural dolapyrrolidone (Dpy, 1), a natural pyrrolidone derived from phenylalanine, for...
5.
Tani H, Mito T, Velagapudi V, Ishikawa K, Umehara M, Nakada K, et al.
Sci Rep
. 2019 Nov;
9(1):16054.
PMID: 31690790
In a previous study, we proposed that age-related mitochondrial respiration defects observed in elderly subjects are partially due to age-associated downregulation of nuclear-encoded genes, including serine hydroxymethyltransferase 2 (SHMT2), which...
6.
Mito T, Tani H, Suzuki M, Ishikawa K, Nakada K, Hayashi J
Exp Anim
. 2018 Jul;
67(4):509-516.
PMID: 29973435
Mitochondrial DNA (mtDNA) mutator mice showing accelerated accumulation of mtDNA with somatic mutations are potentially useful models of human aging, whereas mito-miceΔ showing accelerated accumulation of mtDNA with a deletion...
7.
Sumi C, Okamoto A, Tanaka H, Nishi K, Kusunoki M, Shoji T, et al.
PLoS One
. 2018 Feb;
13(2):e0192796.
PMID: 29447230
The intravenous anesthetic propofol (2,6-diisopropylphenol) has been used for the induction and maintenance of anesthesia and sedation in critical patient care. However, the rare but severe complication propofol infusion syndrome...
8.
Tani H, Ohnishi S, Shitara H, Mito T, Yamaguchi M, Yonekawa H, et al.
Sci Rep
. 2018 Jan;
8(1):425.
PMID: 29323231
Accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been proposed to be responsible for human aging and age-associated mitochondrial respiration defects. However, our previous findings suggested an alternative hypothesis...
9.
Koshikawa N, Akimoto M, Hayashi J, Nagase H, Takenaga K
Sci Rep
. 2017 Nov;
7(1):15535.
PMID: 29138417
Cancer cells have more mutations in their mitochondrial DNA (mtDNA) than do normal cells, and pathogenic mutations in the genes encoding mitochondrial NADH dehydrogenase (ND) subunits have been found to...
10.
Shimizu A, Tani H, Takibuchi G, Ishikawa K, Sakurazawa R, Inoue T, et al.
Biochem Biophys Res Commun
. 2017 Sep;
493(1):252-257.
PMID: 28893537
In a previous study, we generated transmitochondrial P29mtSAMP1 cybrids, which had nuclear DNA from the C57BL6 (referred to as B6) mouse strain-derived P29 tumor cells and mitochondrial DNA (mtDNA) exogenously-transferred...