Julien Spatazza
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Explore the profile of Julien Spatazza including associated specialties, affiliations and a list of published articles.
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13
Citations
884
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Recent Articles
1.
Bershteyn M, Broer S, Parekh M, Maury Y, Havlicek S, Kriks S, et al.
Cell Stem Cell
. 2023 Oct;
30(10):1331-1350.e11.
PMID: 37802038
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are left with suboptimal therapeutic options such as brain tissue-destructive surgery. Here,...
2.
Paredes M, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, et al.
Science
. 2022 Jan;
375(6579):eabk2346.
PMID: 35084970
The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic ventral forebrain. How this germinal zone generates sufficient interneurons for the...
3.
Leon W, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, et al.
Elife
. 2020 Jul;
9.
PMID: 32633719
Cortical function critically depends on inhibitory/excitatory balance. Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into cortex, where their numbers are adjusted by programmed cell death....
4.
Bhaduri A, Di Lullo E, Jung D, Muller S, Crouch E, Espinosa C, et al.
Cell Stem Cell
. 2020 Jan;
26(1):48-63.e6.
PMID: 31901251
Glioblastoma is a devastating form of brain cancer. To identify aspects of tumor heterogeneity that may illuminate drivers of tumor invasion, we created a glioblastoma tumor cell atlas with single-cell...
5.
Priya R, Rakela B, Kaneko M, Spatazza J, Larimer P, Hoseini M, et al.
J Neurosci
. 2019 Feb;
39(14):2635-2648.
PMID: 30705101
The maturation of GABAergic inhibitory circuits is necessary for the onset of the critical period for ocular dominance plasticity (ODP) in the postnatal visual cortex (Hensch, 2005; Espinosa and Stryker,...
6.
Spatazza J, Leon W, Alvarez-Buylla A
Prog Brain Res
. 2017 May;
231:57-85.
PMID: 28554401
Many neurological disorders stem from defects in or the loss of specific neurons. Neuron transplantation has tremendous clinical potential for central nervous system therapy as it may allow for the...
7.
Raju C, Spatazza J, Stanco A, Larimer P, Sorrells S, Kelley K, et al.
Cereb Cortex
. 2017 Apr;
28(6):1946-1958.
PMID: 28449024
The neocortex of primates, including humans, contains more abundant and diverse inhibitory neurons compared with rodents, but the molecular foundations of these observations are unknown. Through integrative gene coexpression analysis,...
8.
Larimer P, Spatazza J, Stryker M, Alvarez-Buylla A, Hasenstaub A
J Neurophysiol
. 2017 Mar;
118(1):131-139.
PMID: 28356470
Interneuron precursors transplanted into visual cortex induce network plasticity during their heterochronic maturation. Such plasticity can have a significant impact on the function of the animal and is normally present...
9.
Retallack H, Di Lullo E, Arias C, Knopp K, Laurie M, Sandoval-Espinosa C, et al.
Proc Natl Acad Sci U S A
. 2016 Dec;
113(50):14408-14413.
PMID: 27911847
The rapid spread of Zika virus (ZIKV) and its association with abnormal brain development constitute a global health emergency. Congenital ZIKV infection produces a range of mild to severe pathologies,...
10.
Larimer P, Spatazza J, Espinosa J, Tang Y, Kaneko M, Hasenstaub A, et al.
Cell Rep
. 2016 Jul;
16(5):1391-1404.
PMID: 27425623
The maturation of inhibitory GABAergic cortical circuits regulates experience-dependent plasticity. We recently showed that the heterochronic transplantation of parvalbumin (PV) or somatostatin (SST) interneurons from the medial ganglionic eminence (MGE)...