Julien Nicolas
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Explore the profile of Julien Nicolas including associated specialties, affiliations and a list of published articles.
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86
Citations
2780
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Recent Articles
1.
Zhu C, Beauseroy H, Mougin J, Lages M, Nicolas J
Chem Sci
. 2025 Jan;
16(6):2619-2633.
PMID: 39822905
The synthesis of degradable polymer prodrug nanoparticles is still a challenge to be met, which would make it possible to remedy both the shortcomings of traditional formulation of preformed polymers...
2.
Martin-Aubert S, Avrillon K, Tournier N, Bordat A, Tran V, Ibrahim N, et al.
J Control Release
. 2024 Dec;
378:803-813.
PMID: 39719212
Mertansine (DM1), a potent tumor-killing maytansinoid, requires conjugation to antibodies or incorporation into nanocarriers due to its high toxicity. However, these carriers often result in undesirable biodistribution, leading to rapid...
3.
Neal T, Nicolas J
Chem Commun (Camb)
. 2024 Nov;
60(96):14260-14263.
PMID: 39540542
We report the successful synthesis of hydrophilic thioester-containing polyacrylamide copolymers by the RAFT and free-radical copolymerisation of dibenzo[,]oxepane-5-thione with either acrylamide or -isopropylacrylamide. These copolymers efficiently degrade in aqueous solutions...
4.
Gumus K, Nicolas J, Gopireddy D, Dolz J, Jazayeri S, Bandyk M
Cancers (Basel)
. 2024 Jul;
16(13).
PMID: 39001410
Background: Bladder cancer (BC) segmentation on MRI images is the first step to determining the presence of muscular invasion. This study aimed to assess the tumor segmentation performance of three...
5.
Guerassimoff L, Ferrere M, Bossion A, Nicolas J
Chem Soc Rev
. 2024 May;
53(12):6511-6567.
PMID: 38775004
Polymer prodrugs are based on the covalent linkage of therapeutic molecules to a polymer structure which avoids the problems and limitations commonly encountered with traditional drug-loaded nanocarriers in which drugs...
6.
Martinez-Camarena A, Bellia F, Paz Clares M, Vecchio G, Nicolas J, Garcia-Espana E
Chemistry
. 2024 Apr;
30(37):e202401331.
PMID: 38687026
Despite decades of research, Parkinson's disease is still an idiopathic pathology for which no cure has yet been found. This is partly explained by the multifactorial character of most neurodegenerative...
7.
Guerassimoff L, Ferrere M, Van Herck S, Dehissi S, Nicolas V, De Geest B, et al.
J Control Release
. 2024 Mar;
369:376-393.
PMID: 38554772
Despite their great versatility and ease of functionalization, most polymer-based nanocarriers intended for use in drug delivery often face serious limitations that can prevent their clinical translation, such as uncontrolled...
8.
Gao P, Ha-Duong T, Nicolas J
Angew Chem Int Ed Engl
. 2024 Feb;
63(12):e202316056.
PMID: 38345287
To achieve drug release from polymer prodrug nanoparticles, the drug-polymer linker must be accessible for cleavage to release the drug, which can occur under certain physiological conditions (e.g., presence of...
9.
Liu N, Gao P, Lu H, Fang L, Nicolas J, Ha-Duong T, et al.
Chemistry
. 2023 Oct;
30(1):e202302669.
PMID: 37823686
Amphiphobic fluoroalkyl chains are exploited for creating robust and diverse self-assembled biomimetic catalysts. Long terminal perfluoroalkyl chains (C F with n=6, 8, and 10) linked with a short perhydroalkyl chains...
10.
Lages M, Pesenti T, Zhu C, Le D, Mougin J, Guillaneuf Y, et al.
Chem Sci
. 2023 Mar;
14(12):3311-3325.
PMID: 36970097
Radical ring-opening polymerization (rROP) has received renewed attention to incorporate cleavable linkages into the backbones of vinyl polymers, especially from cyclic ketene acetals (CKAs). Among the monomers that hardly copolymerize...