Julien Debbache
Overview
Explore the profile of Julien Debbache including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
519
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Recent Articles
1.
Loos B, Salas-Bastos A, Nordin A, Debbache J, Stierli S, Cheng P, et al.
Cell Death Dis
. 2024 Dec;
15(12):925.
PMID: 39709491
The TGFβ signaling pathway is known for its pleiotropic functions in a plethora of biological processes. In melanoma, TGFβ signaling promotes invasiveness and metastasis formation. However, its involvement in the...
2.
Vu H, Valdimarsson M, Sigurbjornsdottir S, Bergsteinsdottir K, Debbache J, Bismuth K, et al.
EMBO Rep
. 2024 Aug;
25(10):4252-4280.
PMID: 39169200
MITF, a basic Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. We perform a genetic screen for suppressors of the Mitf-associated pigmentation...
3.
Vu H, Valdimarsson M, Sigurbjornsdottir S, Bergsteinsdottir K, Debbache J, Bismuth K, et al.
bioRxiv
. 2023 Oct;
PMID: 37786677
MITF, a basic-Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. To explore MITF regulation and its role in melanoma, we conducted a...
4.
Sobecki M, Chen J, Krzywinska E, Nagarajan S, Fan Z, Nelius E, et al.
Cell Stem Cell
. 2022 Sep;
29(10):1459-1474.e9.
PMID: 36113462
Fibrosis is the final path of nearly every form of chronic disease, regardless of the pathogenesis. Upon chronic injury, activated, fibrogenic fibroblasts deposit excess extracellular matrix, and severe tissue fibrosis...
5.
Sobecki M, Krzywinska E, Nagarajan S, Audige A, Hunh K, Zacharjasz J, et al.
Nat Commun
. 2021 Aug;
12(1):4700.
PMID: 34349124
During skin injury, immune response and repair mechanisms have to be coordinated for rapid skin regeneration and the prevention of microbial infections. Natural Killer (NK) cells infiltrate hypoxic skin lesions...
6.
Zingg D, Debbache J, Pena-Hernandez R, Antunes A, Schaefer S, Cheng P, et al.
Cancer Cell
. 2018 Jul;
34(1):69-84.e14.
PMID: 30008323
Human melanomas frequently harbor amplifications of EZH2. However, the contribution of EZH2 to melanoma formation has remained elusive. Taking advantage of murine melanoma models, we show that EZH2 drives tumorigenesis...
7.
Debbache J, Parfejevs V, Sommer L
Genesis
. 2018 Apr;
56(6-7):e23105.
PMID: 29673028
The neural crest is one of the embryonic structures with the broadest developmental potential in vertebrates. Morphologically, neural crest cells emerge during neurulation in the dorsal folds of the neural...
8.
Parfejevs V, Debbache J, Shakhova O, Schaefer S, Glausch M, Wegner M, et al.
Nat Commun
. 2018 Jan;
9(1):236.
PMID: 29339718
Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair...
9.
Shakhova O, Cheng P, Mishra P, Zingg D, Schaefer S, Debbache J, et al.
PLoS Genet
. 2015 Jan;
11(1):e1004877.
PMID: 25629959
Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma...
10.
Zingg D, Debbache J, Schaefer S, Tuncer E, Frommel S, Cheng P, et al.
Nat Commun
. 2015 Jan;
6:6051.
PMID: 25609585
Increased activity of the epigenetic modifier EZH2 has been associated with different cancers. However, evidence for a functional role of EZH2 in tumorigenesis in vivo remains poor, in particular in...