Julien Beyrath
Overview
Explore the profile of Julien Beyrath including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
515
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Recent Articles
1.
Klein Gunnewiek T, Verboven A, Pelgrim I, Hogeweg M, Schoenmaker C, Renkema H, et al.
Stem Cell Reports
. 2021 Jul;
16(9):2197-2212.
PMID: 34329596
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is often caused by an adenine to guanine variant at m.3243 (m.3243A>G) of the MT-TL1 gene. To understand how this pathogenic variant...
2.
Jiang X, Renkema H, Smeitink J, Beyrath J
PLoS One
. 2021 Jul;
16(7):e0254315.
PMID: 34242345
Aggressiveness of cancers, like prostate cancer, has been found to be associated with elevated expression of the microsomal prostaglandin E synthase-1 (mPGES-1). Here, we investigated whether KH176m (the active metabolite...
3.
Schwartzentruber A, Boschian C, Lopes F, Myszczynska M, New E, Beyrath J, et al.
Sci Rep
. 2020 Sep;
10(1):15485.
PMID: 32968089
Mutations in PRKN are the most common cause of early onset Parkinson's disease. Parkin is an E3 ubiquitin ligase, functioning in mitophagy. Mitochondrial abnormalities are present in PRKN mutant models....
4.
Krabbendam I, Honrath B, Dilberger B, Iannetti E, Branicky R, Meyer T, et al.
Cell Death Dis
. 2020 Apr;
11(4):263.
PMID: 32327637
Metabolic flexibility is an essential characteristic of eukaryotic cells in order to adapt to physiological and environmental changes. Especially in mammalian cells, the metabolic switch from mitochondrial respiration to aerobic...
5.
Smeitink J, Koene S, Beyrath J, Saris C, Turnbull D, Janssen M
JIMD Rep
. 2019 Jun;
46(1):52-62.
PMID: 31240155
Migraine, characterized by recurrent attacks of predominantly unilateral throbbing headache, affects approximately 15% of the adult population and is an important cause of disability worldwide. Knowledge required for the development...
6.
Foriel S, Renkema G, Lasarzewski Y, Berkhout J, Rodenburg R, Smeitink J, et al.
Front Genet
. 2019 Apr;
10:245.
PMID: 30972103
Mitochondrial diseases are a group of rare life-threatening diseases often caused by defects in the oxidative phosphorylation system. No effective treatment is available for these disorders. Therapeutic development is hampered...
7.
Iannetti E, Prigione A, Smeitink J, Koopman W, Beyrath J, Renkema H
Front Genet
. 2019 Mar;
10:131.
PMID: 30881379
Mitochondria are best known as the powerhouses of the cells but their cellular role goes far beyond energy production; among others, they have a pivotal function in cellular calcium and...
8.
Iannetti E, Smeitink J, Willems P, Beyrath J, Koopman W
Cell Death Dis
. 2018 Nov;
9(11):1135.
PMID: 30429455
Cell models of mitochondrial complex I (CI) deficiency display activation of glycolysis to compensate for the loss in mitochondrial ATP production. This adaptation can mask other relevant deficiency-induced aberrations in...
9.
Janssen M, Koene S, de Laat P, Hemelaar P, Pickkers P, Spaans E, et al.
Clin Pharmacol Ther
. 2018 Jul;
105(1):101-111.
PMID: 30058726
KH176 is a potent intracellular reduction-oxidation-modulating compound developed to treat mitochondrial disease. We studied tolerability, safety, pharmacokinetics, pharmacodynamics, and efficacy of twice daily oral 100 mg KH176 for 28 days...
10.
Beyrath J, Pellegrini M, Renkema H, Houben L, Pecheritsyna S, van Zandvoort P, et al.
Sci Rep
. 2018 Apr;
8(1):6577.
PMID: 29700325
A deficient activity of one or more of the mitochondrial oxidative phosphorylation (OXPHOS) enzyme complexes leads to devastating diseases, with high unmet medical needs. Mitochondria, and more specifically the OXPHOS...