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Julie Borland

Explore the profile of Julie Borland including associated specialties, affiliations and a list of published articles. Areas
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Articles 30
Citations 725
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Recent Articles
1.
Song I, Zong J, Borland J, Jerva F, Wynne B, Zamek-Gliszczynski M, et al.
J Acquir Immune Defic Syndr . 2016 Mar; 72(4):400-7. PMID: 26974526
Background: Dolutegravir is an integrase strand transfer inhibitor (INSTI) licensed for use in HIV-1 infection and is an inhibitor of organic cation transporter 2 (OCT2). This study assessed the effect...
2.
Song I, Weller S, Patel J, Borland J, Wynne B, Choukour M, et al.
Eur J Clin Pharmacol . 2016 Feb; 72(6):665-70. PMID: 26898568
Purpose: Dolutegravir (DTG) is primarily metabolized by UGT1A1 with CYP3A as a minor route. Carbamazepine (CBZ) is a potent inducer of these enzymes; thus, the effect of oral extended-release CBZ...
3.
Song I, Borland J, Savina P, Chen S, Patel P, Wajima T, et al.
Clin Pharmacol Drug Dev . 2015 Jun; 2(4):342-348. PMID: 26097786
This study evaluated dolutegravir pharmacokinetics (PK) in subjects with moderate hepatic impairment compared to matched, healthy controls. In this open-label, parallel-group study, eight adult subjects with moderate hepatic impairment (Child-Pugh...
4.
Song I, Borland J, Chen S, Wajima T, Peppercorn A, Piscitelli S
Ann Pharmacother . 2015 Apr; 49(7):784-9. PMID: 25862012
Background: Dolutegravir (DTG; Tivicay; ViiV Healthcare, Research Triangle Park, NC) is an HIV-1-unboosted integrase inhibitor with no cytochrome P450 or uridine 5'diphosphate-glucuronosyltransferase inhibition or induction. As DTG is administered to...
5.
Song I, Borland J, Arya N, Wynne B, Piscitelli S
J Clin Pharmacol . 2014 Dec; 55(5):490-6. PMID: 25449994
All commercially available integrase inhibitors are 2-metal binders and may be affected by co-administration with metal cations. The purpose of this study was to evaluate the effect of calcium and...
6.
Zong J, Borland J, Jerva F, Wynne B, Choukour M, Song I
J Int AIDS Soc . 2014 Nov; 17(4 Suppl 3):19584. PMID: 25394090
Introduction: Dolutegravir (DTG) is an HIV integrase strand transfer inhibitor approved for use in combination with other antiretrovirals for the treatment of HIV-infection in adults and adolescents. Metformin is a...
7.
Song I, Borland J, Chen S, Peppercorn A, Wajima T, Piscitelli S
Antimicrob Agents Chemother . 2014 Aug; 58(11):6696-700. PMID: 25155604
Dolutegravir (DTG) is an HIV integrase inhibitor (INI) with demonstrated activity in INI-naive and INI-resistant patients. The objective of this open-label, 2-period, single-sequence study was to evaluate the effect of...
8.
Song I, Borland J, Chen S, Guta P, Lou Y, Wilfret D, et al.
Eur J Clin Pharmacol . 2014 Aug; 70(10):1173-9. PMID: 25146692
Purpose: Dolutegravir (DTG) is an unboosted, integrase inhibitor for the treatment of HIV infection. Two studies evaluated the effects of efavirenz (EFV) and tipranavir/ritonavir (TPV/r) on DTG pharmacokinetics (PK) in...
9.
Johnson M, Borland J, Chen S, Savina P, Wynne B, Piscitelli S
Br J Clin Pharmacol . 2014 May; 78(5):1043-9. PMID: 24838177
Aims: The aim was to evaluate the effect of boceprevir and telaprevir on dolutegravir pharmacokinetics (PK); the effect of dolutegravir on boceprevir and telaprevir PK was assessed through comparison with...
10.
Weller S, Chen S, Borland J, Savina P, Wynne B, Piscitelli S
J Acquir Immune Defic Syndr . 2014 May; 66(4):393-8. PMID: 24798770
Background: The integrase inhibitor dolutegravir and nucleoside analogues abacavir and lamivudine are once-daily treatment options for HIV. This study (NCT01622790) evaluated, first, the bioequivalence (BE) of a fixed-dose combination (FDC)...