Julian G Molotkovsky
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Explore the profile of Julian G Molotkovsky including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
577
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Recent Articles
1.
Gao Y, Zhai X, Boldyrev I, Molotkovsky J, Patel D, Malinina L, et al.
J Biol Chem
. 2021 Mar;
296:100600.
PMID: 33781749
Ceramide-1-phosphate transfer proteins (CPTPs) are members of the glycolipid transfer protein (GLTP) superfamily that shuttle ceramide-1-phosphate (C1P) between membranes. CPTPs regulate cellular sphingolipid homeostasis in ways that impact programmed cell...
2.
Gao Y, Le L, Zhai X, Boldyrev I, Mishra S, Tischer A, et al.
Anal Chem
. 2020 Jan;
92(4):3417-3425.
PMID: 31970977
In vitro assessment of lipid intermembrane transfer activity by cellular proteins typically involves measurement of either radiolabeled or fluorescently labeled lipid trafficking between vesicle model membranes. Use of bilayer vesicles...
3.
Ochoa-Lizarralde B, Gao Y, Popov A, Samygina V, Zhai X, Mishra S, et al.
J Biol Chem
. 2018 Sep;
293(43):16709-16723.
PMID: 30206120
The glycolipid transfer protein (GLTP) fold defines a superfamily of eukaryotic proteins that selectively transport sphingolipids (SLs) between membranes. However, the mechanisms determining the protein selectivity for specific glycosphingolipids (GSLs)...
4.
Gorbenko G, Trusova V, Molotkovsky J
J Fluoresc
. 2017 Sep;
28(1):79-88.
PMID: 28879486
Specific interactions between a mitochondrial hemoprotein cytochrome c (cyt c) and cardiolipin, a lipid component of mitochondrial membrane, are crucial to electron shuttling and apoptotic activities of this protein. In...
5.
Alekseeva A, Moiseeva E, Onishchenko N, Boldyrev I, Singin A, Budko A, et al.
Int J Nanomedicine
. 2017 May;
12:3735-3749.
PMID: 28553111
In a previous study, a formulation of methotrexate (MTX) incorporated in the lipid bilayer of 100-nm liposomes in the form of diglyceride ester (MTX-DG, lipophilic prodrug) was developed. In this...
6.
Zhai X, Gao Y, Mishra S, Simanshu D, Boldyrev I, Benson L, et al.
J Biol Chem
. 2016 Dec;
292(6):2531-2541.
PMID: 28011644
Genetic models for studying localized cell suicide that halt the spread of pathogen infection and immune response activation in plants include mutant (). In this mutant, sphingolipid homeostasis is disrupted...
7.
Malinina L, Simanshu D, Zhai X, Samygina V, Kamlekar R, Kenoth R, et al.
Q Rev Biophys
. 2015 Mar;
48(3):281-322.
PMID: 25797198
Glycolipid transfer proteins (GLTPs) originally were identified as small (~24 kDa), soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. GLTPs and related homologs now are known to...
8.
Zhai X, Boldyrev I, Mizuno N, Momsen M, Molotkovsky J, Brockman H, et al.
Langmuir
. 2014 Feb;
30(11):3154-64.
PMID: 24564829
Phosphatidycholines (PC) with two saturated acyl chains (e.g., dipalmitoyl) mimic natural sphingomyelin (SM) by promoting raft formation in model membranes. However, sphingoid-based lipids, such as SM, rather than saturated-chain PCs...
9.
Simanshu D, Zhai X, Munch D, Hofius D, Markham J, Bielawski J, et al.
Cell Rep
. 2014 Jan;
6(2):388-99.
PMID: 24412362
The accelerated cell death 11 (acd11) mutant of Arabidopsis provides a genetic model for studying immune response activation and localized cellular suicide that halt pathogen spread during infection in plants....
10.
Simanshu D, Kamlekar R, Wijesinghe D, Zou X, Zhai X, Mishra S, et al.
Nature
. 2013 Jul;
500(7463):463-7.
PMID: 23863933
Phosphorylated sphingolipids ceramide-1-phosphate (C1P) and sphingosine-1-phosphate (S1P) have emerged as key regulators of cell growth, survival, migration and inflammation. C1P produced by ceramide kinase is an activator of group IVA...