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Julian Braybrook

Explore the profile of Julian Braybrook including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 125
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Recent Articles
1.
Kontogiannis T, Braybrook J, McElroy C, Foy C, Whale A, Quaglia M, et al.
Mol Ther Methods Clin Dev . 2024 Sep; 32(3):101309. PMID: 39234444
Standardized evaluation of adeno-associated virus (AAV) vector products for biotherapeutic application is essential to ensure the safety and efficacy of gene therapies. This includes analyzing the critical quality attributes of...
2.
Huggett J, OSullivan D, Cowen S, Cleveland M, Davies K, Harris K, et al.
Mol Aspects Med . 2024 May; 97:101275. PMID: 38772082
Diagnostic tests were heralded as crucial during the Coronavirus disease (COVID-19) pandemic with most of the key methods using bioanalytical approaches that detected larger molecules (RNA, protein antigens or antibodies)...
3.
Sammut-Powell C, Reynard C, Allen J, McDermott J, Braybrook J, Parisi R, et al.
Diagn Progn Res . 2022 Apr; 6(1):12. PMID: 35468850
Background: In response to the global COVID-19 pandemic, many in vitro diagnostic (IVD) tests for SARS-CoV-2 have been developed. Given the urgent clinical demand, researchers must balance the desire for...
4.
Cheung M, Campbell J, Thomas R, Braybrook J, Petzing J
Int J Mol Sci . 2022 Mar; 23(6). PMID: 35328645
Flow cytometry is widely used within the manufacturing of cell and gene therapies to measure and characterise cells. Conventional manual data analysis relies heavily on operator judgement, presenting a major...
5.
Cheung M, Campbell J, Thomas R, Braybrook J, Petzing J
PDA J Pharm Sci Technol . 2022 Jan; 76(3):200-215. PMID: 35031542
Application of synthetic datasets in training and validation of analysis tools has led to improvements in many decision-making tasks in a range of domains from computer vision to digital pathology....
6.
Evans D, Cowen S, Kammel M, OSullivan D, Stewart G, Grunert H, et al.
Clin Chem . 2021 Oct; 68(1):153-162. PMID: 34633030
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA quantities, measured by reverse transcription quantitative PCR (RT-qPCR), have been proposed to stratify clinical risk or determine analytical performance targets. We...
7.
Grant R, Coopman K, Silva-Gomes S, Campbell J, Kara B, Braybrook J, et al.
Methods Protoc . 2021 Apr; 4(2). PMID: 33808088
Measured variability of product within Cell and Gene Therapy (CGT) manufacturing arises from numerous sources across pre-analytical to post-analytical phases of testing. Operators are a function of the manufacturing process...
8.
Cheung M, Campbell J, Whitby L, Thomas R, Braybrook J, Petzing J
Cytometry A . 2021 Feb; 99(10):1007-1021. PMID: 33606354
Automated flow cytometry (FC) data analysis tools for cell population identification and characterization are increasingly being used in academic, biotechnology, pharmaceutical, and clinical laboratories. The development of these computational methods...
9.
Grant R, Coopman K, Medcalf N, Silva-Gomes S, Campbell J, Kara B, et al.
PDA J Pharm Sci Technol . 2020 Oct; 75(1):33-47. PMID: 33067330
Flow cytometry is a complex measurement characterization technique, utilized within the manufacture, measurement, and release of cell and gene therapy products for rapid, high-content, and multiplexed discriminatory cell analysis. A...
10.
Struwe W, Emmott E, Bailey M, Sharon M, Sinz A, Corrales F, et al.
Lancet . 2020 May; 395(10239):1761-1762. PMID: 32473097
No abstract available.