Julia M Adam
Overview
Explore the profile of Julia M Adam including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
105
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0
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Recent Articles
1.
Omar F, Findlay J, Carfray G, Allcock R, Jiang Z, Moore C, et al.
Proc Natl Acad Sci U S A
. 2019 Jun;
116(27):13320-13329.
PMID: 31209056
Cyclic AMP (cAMP) phosphodiesterase-4 (PDE4) enzymes degrade cAMP and underpin the compartmentalization of cAMP signaling through their targeting to particular protein complexes and intracellular locales. We describe the discovery and...
2.
Adam J, Clark J, Davies K, Everett K, Fields R, Francis S, et al.
Bioorg Med Chem Lett
. 2012 Mar;
22(8):2932-7.
PMID: 22421020
Novel, low brain penetrant, orally bioavailable CB1 receptor agonists were designed starting from a mature lead series of potent brain penetrant CB1 receptor agonists. Increasing the calculated polar surface area...
3.
Ratcliffe P, Adam J, Baker J, Bursi R, Campbell R, Clark J, et al.
Bioorg Med Chem Lett
. 2011 Mar;
21(8):2541-6.
PMID: 21411321
We report an expansion of the structure-activity relationship (SAR) of a novel series of indole-3-heterocyclic CB1 receptor agonists. Starting from the potent but poorly soluble lead, 1, a rational approach...
4.
Kiyoi T, Adam J, Clark J, Davies K, Easson A, Edwards D, et al.
Bioorg Med Chem Lett
. 2011 Feb;
21(6):1748-53.
PMID: 21316962
Novel 3-(1H-indol-3-yl)-1,2,4-oxadiazoles and -thiadiazoles were synthesized and found to be potent CB1 cannabinoid receptor agonists. The oral bioavailability of these compounds could be dramatically improved by optimization studies of the...
5.
Morrison A, Adam J, Baker J, Campbell R, Clark J, Cottney J, et al.
Bioorg Med Chem Lett
. 2010 Nov;
21(1):506-9.
PMID: 21075630
Novel indole-3-heterocycles were designed and synthesized and found to be potent CB1 receptor agonists. Starting from a microsomally unstable lead 1, a bioisostere approach replacing a piperazine amide was undertaken....
6.
Moir E, Yoshiizumi K, Cairns J, Cowley P, Ferguson M, Jeremiah F, et al.
Bioorg Med Chem Lett
. 2010 Nov;
20(24):7327-30.
PMID: 21074434
Bicyclic piperazine derivatives were synthesized as conformationally constrained analogs of N-alkyl piperazines and were found to be potent CB1 receptor agonists. The CB1 receptor agonist activity was dependent upon the...
7.
Kiyoi T, York M, Francis S, Edwards D, Walker G, Houghton A, et al.
Bioorg Med Chem Lett
. 2010 Jul;
20(16):4918-21.
PMID: 20634067
Novel tricyclic indole-3-carboxamides were synthesized as structurally restricted analogs of bicyclic indoles, and found to be potent CB1 cannabinoid receptor agonists. The CB1 agonist activity depended on the absolute configuration...
8.
Adam J, Bennett D, Bom A, Clark J, Feilden H, Hutchinson E, et al.
J Med Chem
. 2002 Apr;
45(9):1806-16.
PMID: 11960492
A series of mono- and per-6-substituted cyclodextrin derivatives were synthesized as synthetic receptors (or host molecules) of rocuronium bromide, the most widely used neuromuscular blocker in anaesthesia. By forming host-guest...