Jui-Hua Hsieh
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Explore the profile of Jui-Hua Hsieh including associated specialties, affiliations and a list of published articles.
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64
Citations
1275
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Recent Articles
1.
Ooka M, Zhao J, Zhang L, Huang R, Sakamuru S, TeKrony C, et al.
Environ Sci Technol
. 2025 Mar;
PMID: 40047063
Superfund sites are where soil, air, and water are polluted with hazardous materials. Individuals residing and working in these areas are often exposed to metals and other hazardous materials, leading...
2.
Hsu J, Hsu K, Chou C, He T, Lin T, Sung T, et al.
Biomed Pharmacother
. 2025 Feb;
184:117891.
PMID: 39955852
Cyclin-dependent kinase 8 (CDK8) plays a crucial role in the transforming growth factor beta (TGF-β) signaling pathway, which is critical to the pathology of idiopathic pulmonary fibrosis (IPF). CDK8 promotes...
3.
Lin T, Chou C, Wu Y, Sung T, Hsu J, Yen S, et al.
J Chem Inf Model
. 2024 Dec;
65(1):378-389.
PMID: 39740163
Pulmonary fibrosis is excessive scarring of the lung tissues. Transforming growth factor-beta (TGF-β) has been implicated in pulmonary fibrosis due to its ability to induce the epithelial-to-mesenchymal transition (EMT) and...
4.
Chen J, Tu H, Lin T, Peng Z, Wu Y, Yen S, et al.
Biomed Pharmacother
. 2024 Nov;
181:117688.
PMID: 39591664
The dual-specificity tyrosine-phosphorylation-regulated kinase 1 A (DYRK1A) presents a promising therapeutic target for neurological diseases. However, current inhibitors lack selectivity, which can lead to unexpected side effects and increase the...
5.
Mansouri K, Taylor K, Auerbach S, Ferguson S, Frawley R, Hsieh J, et al.
Environ Health Perspect
. 2024 Aug;
132(8):85002.
PMID: 39106156
Background: The field of toxicology has witnessed substantial advancements in recent years, particularly with the adoption of new approach methodologies (NAMs) to understand and predict chemical toxicity. Class-based methods such...
6.
Kreutz A, Oyetade O, Chang X, Hsieh J, Behl M, Allen D, et al.
Toxics
. 2024 Jun;
12(6).
PMID: 38922117
Organophosphorus flame retardants (OPFRs) are abundant and persistent in the environment but have limited toxicity information. Their similarity in structure to organophosphate pesticides presents great concern for developmental neurotoxicity (DNT)....
7.
Lin T, Yen D, HuangFu W, Wu Y, Hsu J, Yen S, et al.
Protein Sci
. 2024 May;
33(6):e5007.
PMID: 38723187
The identification of an effective inhibitor is an important starting step in drug development. Unfortunately, many issues such as the characterization of protein binding sites, the screening library, materials for...
8.
Hamm J, Hsieh J, Roberts G, Collins B, Gorospe J, Sparrow B, et al.
Toxics
. 2024 Jan;
12(1).
PMID: 38276729
Embryonic zebrafish represent a useful test system to screen substances for their ability to perturb development. The exposure scenarios, endpoints captured, and data analysis vary among the laboratories who conduct...
9.
Corrigendum: Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis
Combs P, Erickson J, Hsieh J, Guo K, Nolte S, Schmitt C, et al.
Front Toxicol
. 2023 Sep;
5:1278066.
PMID: 37692902
[This corrects the article DOI: 10.3389/ftox.2023.1147608.].
10.
Combs P, Erickson J, Hsieh J, Guo K, Nolte S, Schmitt C, et al.
Front Toxicol
. 2023 Jul;
5:1147608.
PMID: 37441091
Inference of toxicological and mechanistic properties of untested chemicals through structural or biological similarity is a commonly employed approach for initial chemical characterization and hypothesis generation. We previously developed a...