Jue Zeng
Overview
Explore the profile of Jue Zeng including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
924
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0
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Recent Articles
1.
Huang Y, Sendzik M, Zhang J, Gao Z, Sun Y, Wang L, et al.
J Med Chem
. 2022 Mar;
65(7):5317-5333.
PMID: 35352560
Polycomb Repressive Complex 2 (PRC2) plays an important role in transcriptional regulation during animal development and in cell differentiation, and alteration of PRC2 activity has been associated with cancer. On...
2.
Chen X, Zhao L, Yu T, Zeng J, Chen M
Am J Transl Res
. 2022 Feb;
14(1):197-210.
PMID: 35173838
Background: Serine peptidase inhibitor Kazal type 2 (SPINK2) has been reported to be involved in certain cancers. We conducted an in-depth investigation on the role and mechanism of SPINK2 in...
3.
Chen X, Yang S, Zeng J, Chen M
Mol Med Rep
. 2018 Nov;
19(1):508-514.
PMID: 30483794
MicroRNAs (miRNAs) have been demonstrated to regulate the progression of numerous types of cancer, including acute myeloid leukemia (AML). Previous studies demonstrated that miR‑1271‑5p functions as a tumor suppressor; however,...
4.
Qi W, Zhao K, Gu J, Huang Y, Wang Y, Zhang H, et al.
Nat Chem Biol
. 2017 Jan;
13(4):381-388.
PMID: 28135235
Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 methylates histone H3 lysine 27...
5.
Li L, Feng L, Shi M, Zeng J, Chen Z, Zhong L, et al.
Anal Biochem
. 2017 Jan;
522:37-45.
PMID: 28111304
The EED (embryonic ectoderm development) subunit of the Polycomb repressive complex 2 (PRC2) plays an important role in the feed forward regulation of the PRC2 enzymatic activity. We recently identified...
6.
Huang Y, Zhang J, Yu Z, Zhang H, Wang Y, Lingel A, et al.
J Med Chem
. 2017 Jan;
60(6):2215-2226.
PMID: 28092155
Overexpression and somatic heterozygous mutations of EZH2, the catalytic subunit of polycomb repressive complex 2 (PRC2), are associated with several tumor types. EZH2 inhibitor, EPZ-6438 (tazemetostat), demonstrated clinical efficacy in...
7.
Lingel A, Sendzik M, Huang Y, Shultz M, Cantwell J, Dillon M, et al.
J Med Chem
. 2016 Dec;
60(1):415-427.
PMID: 27992714
PRC2 is a multisubunit methyltransferase involved in epigenetic regulation of early embryonic development and cell growth. The catalytic subunit EZH2 methylates primarily lysine 27 of histone H3, leading to chromatin...
8.
Qi W, Chan H, Teng L, Li L, Chuai S, Zhang R, et al.
Proc Natl Acad Sci U S A
. 2012 Dec;
109(52):21360-5.
PMID: 23236167
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27)...
9.
Cai Z, Chen Y, Zeng J
Zhongguo Zhong Xi Yi Jie He Za Zhi
. 2009 Apr;
29(2):156-8.
PMID: 19382479
Objective: To investigate the clinical curative effect of Lianhuang Decoction (LHD) in treating fetomaternal ABO blood group incompatibility (FM-ABOI). Methods: Sixty pregnancy women diagnosed as FM-ABOI were randomly assigned to...
10.
Zeng J, Yan J, Wang T, Mosbrook-Davis D, Dolan K, Christensen R, et al.
Nucleic Acids Res
. 2007 Dec;
36(1):e8.
PMID: 18086703
Knowledge of all binding sites for transcriptional activators and repressors is essential for computationally aided identification of transcriptional networks. The techniques developed for defining the binding sites of transcription factors...