Judith F Ashouri
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Explore the profile of Judith F Ashouri including associated specialties, affiliations and a list of published articles.
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16
Citations
446
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Recent Articles
1.
McCarthy E, Yu S, Perlmutter N, Nakao Y, Naito R, Lin C, et al.
J Clin Invest
. 2024 Nov;
135(2.
PMID: 39589811
The development of pathogenic autoreactive CD4+ T cells, particularly in the context of impaired signaling, remains poorly understood. Unraveling how defective signaling pathways contribute to their activation and persistence is...
2.
Worzner K, Zimmermann J, Buhl R, Desoi A, Christensen D, Dietrich J, et al.
J Autoimmun
. 2024 Feb;
144:103174.
PMID: 38377868
In many autoimmune diseases, autoantigen-specific Th17 cells play a pivotal role in disease pathogenesis. Th17 cells can transdifferentiate into other T cell subsets in inflammatory conditions, however, there have been...
3.
Mohamedaly S, Levy C, Korsholm C, Alkhani A, Rosenberg K, Ashouri J, et al.
J Clin Med
. 2022 Sep;
11(18).
PMID: 36142937
Biliary atresia (BA) is a rapidly progressive perinatal inflammatory disease, resulting in liver failure. Hepatic Ly6CLo non-classical monocytes promote the resolution of perinatal liver inflammation during rhesus rotavirus-mediated (RRV) BA...
4.
Ashouri J, Lo W, Nguyen T, Shen L, Weiss A
Immunol Rev
. 2021 Dec;
307(1):145-160.
PMID: 34923645
Establishing both central and peripheral tolerance requires the appropriate TCR signaling strength to discriminate self- from agonist-peptide bound to self MHC molecules. ZAP70, a cytoplasmic tyrosine kinase, directly interacts with...
5.
Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, et al.
Front Immunol
. 2021 Jun;
12:638066.
PMID: 34177888
There is an urgent need to identify biomarkers for diagnosis and disease activity monitoring in rheumatoid arthritis (RA). We leveraged publicly available microarray gene expression data in the NCBI GEO...
6.
Shams S, Martinez J, Dawson J, Flores J, Gabriel M, Garcia G, et al.
Front Pharmacol
. 2021 Jun;
12:680043.
PMID: 34122106
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many...
7.
Jiang Y, Jarr K, Layton C, Gardner C, Ashouri J, Abreu M, et al.
Nutrients
. 2021 Apr;
13(3).
PMID: 33801883
Despite being a focal issue to patients, the effect of diet on adult inflammatory bowel disease (IBD) remains underexplored with limited guidance. While promising clinical trials are currently underway, there...
8.
Dhariwala M, Karthikeyan D, Vasquez K, Farhat S, Weckel A, Taravati K, et al.
Cell Rep Med
. 2020 Dec;
1(8):100132.
PMID: 33294857
Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and...
9.
Jadhav P, Jiang Y, Jarr K, Layton C, Ashouri J, Sinha S
Nutrients
. 2020 Jul;
12(7).
PMID: 32698454
The microbiome is an important contributor to a variety of fundamental aspects of human health, including host metabolism, infection, and the immune response. Gut dysbiosis has been identified as a...
10.
Ashouri J, Hsu L, Yu S, Rychkov D, Chen Y, Cheng D, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(37):18517-18527.
PMID: 31455730
How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77-a marker of T cell antigen receptor (TCR) signaling-to identify antigen-activated...