Juan P Fededa
Overview
Explore the profile of Juan P Fededa including associated specialties, affiliations and a list of published articles.
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7
Citations
702
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Recent Articles
1.
Wightman F, Lukin J, Giusti S, Soutschek M, Bragado L, Pozzi B, et al.
Nucleic Acids Res
. 2024 Feb;
52(6):3358-3374.
PMID: 38381063
A subset of circular RNAs (circRNAs) and linear RNAs have been proposed to 'sponge' or block microRNA activity. Additionally, certain RNAs induce microRNA destruction through the process of Target RNA-Directed...
2.
Paolino M, Koglgruber R, Cronin S, Uribesalgo I, Rauscher E, Harreiter J, et al.
Nature
. 2020 Dec;
589(7842):442-447.
PMID: 33361811
Successful pregnancies rely on adaptations within the mother, including marked changes within the immune system. It has long been known that the thymus, the central lymphoid organ, changes markedly during...
3.
Zhong Q, Busetto A, Fededa J, Buhmann J, Gerlich D
Nat Methods
. 2012 May;
9(7):711-3.
PMID: 22635062
Analysis of cellular phenotypes in large imaging data sets conventionally involves supervised statistical methods, which require user-annotated training data. This paper introduces an unsupervised learning method, based on temporally constrained...
4.
Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1
Toscano M, Campagna L, Molinero L, Cerliani J, Croci D, Ilarregui J, et al.
Mol Immunol
. 2011 Jun;
48(15-16):1940-9.
PMID: 21689853
The inflammatory response is a self-limiting process which involves the sequential activation of signaling pathways leading to the production of both pro- and anti-inflammatory mediators. Galectin-1 (Gal-1), an endogenous lectin...
5.
Allo M, Buggiano V, Fededa J, Petrillo E, Schor I, Mata M, et al.
Nat Struct Mol Biol
. 2009 Jun;
16(7):717-24.
PMID: 19543290
When targeting promoter regions, small interfering RNAs (siRNAs) trigger a previously proposed pathway known as transcriptional gene silencing by promoting heterochromatin formation. Here we show that siRNAs targeting intronic or...
6.
Fededa J, Petrillo E, Gelfand M, Neverov A, Kadener S, Nogues G, et al.
Mol Cell
. 2005 Aug;
19(3):393-404.
PMID: 16061185
Alternative splicing plays a key role in generating protein diversity. Transfections with minigenes revealed coordination between two distant, alternatively spliced exons in the same gene. Mutations that either inhibit or...
7.
Mata M, Alonso C, Kadener S, Fededa J, Blaustein M, Pelisch F, et al.
Mol Cell
. 2003 Oct;
12(2):525-32.
PMID: 14536091
Changes in promoter structure and occupation have been shown to modify the splicing pattern of several genes, evidencing a coupling between transcription and alternative splicing. It has been proposed that...