Juan Luiz Coelho-Silva
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Explore the profile of Juan Luiz Coelho-Silva including associated specialties, affiliations and a list of published articles.
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20
Citations
130
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Recent Articles
1.
Rojas C, Pereira-Martins D, Bellido More C, Sternadt D, Weinhauser I, Hilberink J, et al.
Br J Haematol
. 2024 Apr;
204(6):2287-2300.
PMID: 38651345
Despite advancements in utilizing genetic markers to enhance acute myeloid leukaemia (AML) outcome prediction, significant disease heterogeneity persists, hindering clinical management. To refine survival predictions, we assessed the transcriptome of...
2.
Lipreri da Silva J, Coelho-Silva J, Vicari H, Lima K, Rego E, Traina F, et al.
Hematol Transfus Cell Ther
. 2023 Aug;
46(1):101-105.
PMID: 37541806
No abstract available.
3.
Lima K, Pereira-Martins D, de Miranda L, Coelho-Silva J, da Silva Leandro G, Weinhauser I, et al.
Blood Cancer J
. 2022 Nov;
12(11):151.
PMID: 36347832
The treatment of acute leukemia is challenging because of the genetic heterogeneity between and within patients. Leukemic stem cells (LSCs) are relatively drug-resistant and frequently relapse. Their plasticity and capacity...
4.
de Miranda L, Lima K, Coelho-Silva J, Traina F, Kobayashi S, Machado-Neto J
Sci Rep
. 2022 Oct;
12(1):17092.
PMID: 36224313
Combination therapies or multi-targeted drugs have been pointed out as an option to prevent the emergence of resistant clones, which could make long-term treatment more effective and translate into better...
5.
Fernandes J, Fenerich B, Alves-Silva A, Fonseca N, Coelho-Silva J, Scheucher P, et al.
Toxicol In Vitro
. 2022 May;
83:105384.
PMID: 35568132
Myeloproliferative neoplasms (MPN) belong to a group of clonal diseases of hematopoietic stem cells characterized by aberrant proliferation of mature myeloid lineages. The constitutive activation of the JAK2/STAT signaling pathway...
6.
Alves-Silva A, Fenerich B, Fonseca N, Fernandes J, Coelho-Silva J, Pereira-Martins D, et al.
Invest New Drugs
. 2022 Jan;
40(3):576-585.
PMID: 35015172
Background: Myeloproliferative neoplasms (MPN) are disorders characterized by an alteration at the hematopoietic stem cell (HSC) level, where the JAK2 mutation is the most common genetic alteration found in classic...
7.
Vicari H, Coelho-Silva J, Pereira-Martins D, Lucena-Araujo A, Lima K, Lipreri da Silva J, et al.
Invest New Drugs
. 2021 Nov;
40(2):438-452.
PMID: 34837603
Stathmin 1 (STMN1) is a microtubule-destabilizing protein highly expressed in hematological malignancies and involved in proliferation and differentiation. Although a previous study found that the PML-RARα fusion protein, which contributes...
8.
Takei H, Coelho-Silva J, Tavares Leal C, Queiroz Arantes Rocha A, Bianco T, Welner R, et al.
Cancer Sci
. 2021 Nov;
113(2):597-608.
PMID: 34808021
Several lines of research suggest that Bcl-xL-mediated anti-apoptotic effects may contribute to the pathogenesis of myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock-in...
9.
Lipreri da Silva J, Coelho-Silva J, Lima K, Vicari H, Lazarini M, Costa-Lotufo L, et al.
Cell Oncol (Dordr)
. 2021 Jul;
44(5):1105-1117.
PMID: 34196912
Purpose: Despite great advances that have been made in the understanding of the molecular complexity of acute myeloid leukemia (AML), very little has been translated into new therapies. Here, we...
10.
Pereira-Martins D, Weinhauser I, Coelho-Silva J, Franca-Neto P, Almeida L, Bianco T, et al.
Cell Death Dis
. 2021 Apr;
12(4):371.
PMID: 33824267
Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerted...