Juan L Iovanna
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Explore the profile of Juan L Iovanna including associated specialties, affiliations and a list of published articles.
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139
Citations
8751
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Recent Articles
1.
El Kaoutari A, Fraunhoffer N, Audebert S, Camoin L, Berthois Y, Gayet O, et al.
EBioMedicine
. 2023 May;
92:104634.
PMID: 37257316
Background: Pancreatic ductal adenocarcinoma (PDAC) has been widely studied at multiomics level. However, little is known about its specific ubiquitination, a major post-translational modification (PTM). As PTMs regulate the final...
2.
Almada L, Barroso K, Sen S, Toruner M, Sigafoos A, Raja Arul G, et al.
Biochim Biophys Acta Gene Regul Mech
. 2023 Feb;
1866(2):194924.
PMID: 36842643
Upon accumulation of improperly folded proteins in the Endoplasmic Reticulum (ER), the Unfolded Protein Response (UPR) is triggered to restore ER homeostasis. The induction of stress genes is a sine...
3.
Murayama M, Hirata H, Shiraki M, Iovanna J, Yamaza T, Kukita T, et al.
J Cell Physiol
. 2023 Jan;
238(3):566-581.
PMID: 36715607
Nuclear protein 1 (NUPR1) is a stress-induced protein activated by various stresses, such as inflammation and oxidative stress. We previously reported that Nupr1 deficiency increased bone volume by enhancing bone...
4.
Rizzuti B, Iovanna J, Neira J
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499669
The oncoprotein Myc is a transcription factor regulating global gene expression and modulating cell proliferation, apoptosis, and metabolism. Myc has a nuclear localization sequence (NLS) comprising residues Pro320 to Asp328,...
5.
A Transcriptomic-Based Tool to Predict Gemcitabine Sensitivity in Advanced Pancreatic Adenocarcinoma
Fraunhoffer N, Chanez B, Teyssedou C, Iovanna J, Mitry E, Dusetti N
Gastroenterology
. 2022 Dec;
164(3):476-480.e4.
PMID: 36496056
No abstract available.
6.
Estaras M, Ortiz-Placin C, Castillejo-Rufo A, Fernandez-Bermejo M, Blanco G, Mateos J, et al.
J Physiol Biochem
. 2022 Nov;
79(1):235-249.
PMID: 36334253
We have investigated the effects of melatonin on major pathways related with cellular proliferation and energetic metabolism in pancreatic stellate cells. In the presence of melatonin (1 mM, 100 µM,...
7.
Hogenson T, Xie H, Phillips W, Toruner M, Li J, Horn I, et al.
JCI Insight
. 2022 Oct;
7(22).
PMID: 36256477
BACKGROUNDA patient-derived organoid (PDO) platform may serve as a promising tool for translational cancer research. In this study, we evaluated PDO's ability to predict clinical response to gastrointestinal (GI) cancers.METHODSWe...
8.
Nigri J, Leca J, Tubiana S, Finetti P, Guillaumond F, Martinez S, et al.
Sci Signal
. 2022 Aug;
15(745):eabg8191.
PMID: 35917363
In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells is implicated in metastatic progression. Tumor-stroma cross-talk is often mediated through extracellular vesicles (EVs). We previously reported that EVs derived from...
9.
Zhang W, Dhumal D, Zhu X, Ralahy B, Ellert-Miklaszewska A, Wu J, et al.
Chemistry
. 2022 Jul;
28(58):e202201400.
PMID: 35820051
Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to...
10.
Estaras M, Martinez R, Garcia A, Ortiz-Placin C, Iovanna J, Santofimia-Castano P, et al.
Biochem Pharmacol
. 2022 Jun;
202:115118.
PMID: 35671789
Pancreatic stellate cells (PSCs), the main cell type responsible for the development of fibrosis in pancreatic cancer, proliferate actively under hypoxia. Melatonin has received attention as a potential antifibrotic agent...