Juan-Carlos Espinosa
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Explore the profile of Juan-Carlos Espinosa including associated specialties, affiliations and a list of published articles.
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15
Citations
261
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Recent Articles
1.
Toivonen J, Sanz-Rubio D, Lopez-Perez O, Marin-Moreno A, Bolea R, Osta R, et al.
Biomolecules
. 2020 Jun;
10(6).
PMID: 32549330
MicroRNAs (miRNAs) may contribute to the development and pathology of many neurodegenerative diseases, including prion diseases. They are also promising biomarker candidates due to their stability in body fluids. We...
2.
Cassard H, Huor A, Espinosa J, Douet J, Lugan S, Aron N, et al.
mBio
. 2020 Jun;
11(3).
PMID: 32546613
Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently classified according to the methionine/valine polymorphism at codon 129 of the gene and the proteinase K-digested abnormal prion protein (PrP) isoform identified by...
3.
Torres J, Marin-Moreno A, Andreoletti O, Espinosa J, Beringue V, Aguilar P, et al.
Food Saf (Tokyo)
. 2020 Apr;
4(4):105-109.
PMID: 32231913
Dietary exposure to Bovine Spongiform Encephalopathy (BSE) contaminated bovine tissues is considered as the origin of variant Creutzfeldt-Jakob disease (vCJD) in humans. To date, BSE agent is the only recognized...
4.
Mata A, Urrea L, Vilches S, Llorens F, Thune K, Espinosa J, et al.
Mol Neurobiol
. 2016 Oct;
54(8):6412-6425.
PMID: 27726110
Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are...
5.
Aguilar-Calvo P, Espinosa J, Andreoletti O, Gonzalez L, Orge L, Juste R, et al.
Vet Res
. 2016 Sep;
47(1):96.
PMID: 27659200
Host prion (PrP) genotype is a major determinant for the susceptibility to prion diseases. The Q/K-PrP polymorphic variant provides goats and mice with high resistance against classical scrapie and bovine...
6.
Marin-Moreno A, Espinosa J, Fernandez-Borges N, Piquer J, Girones R, Andreoletti O, et al.
Environ Res
. 2016 Sep;
151:587-594.
PMID: 27591838
The environment plays a key role in horizontal transmission of prion diseases, since prions are extremely resistant to classical inactivation procedures. In prior work, we observed the high stability of...
7.
Aguilar-Calvo P, Fast C, Tauscher K, Espinosa J, Groschup M, Nadeem M, et al.
J Infect Dis
. 2015 Feb;
212(4):664-72.
PMID: 25722297
Background: The prion protein-encoding gene (PRNP) is one of the major determinants for scrapie occurrence in sheep and goats. However, its effect on bovine spongiform encephalopathy (BSE) transmission to goats...
8.
Cassard H, Torres J, Lacroux C, Douet J, Benestad S, Lantier F, et al.
Nat Commun
. 2014 Dec;
5:5821.
PMID: 25510416
Although Bovine Spongiform Encephalopathy (BSE) is the cause of variant Creutzfeldt Jakob disease (vCJD) in humans, the zoonotic potential of scrapie prions remains unknown. Mice genetically engineered to overexpress the...
9.
Torres J, Espinosa J, Aguilar-Calvo P, Herva M, Relano-Gines A, Villa-Diaz A, et al.
PLoS One
. 2014 Mar;
9(3):e89722.
PMID: 24608126
The specific characteristics of Transmissible Spongiform Encephalopathy (TSE) strains may be altered during passage across a species barrier. In this study we investigated the biochemical and biological characteristics of Bovine...
10.
Torres J, Castilla J, Pintado B, Gutierrez-Adan A, Andreoletti O, Aguilar-Calvo P, et al.
Emerg Infect Dis
. 2013 Nov;
19(12):1938-47.
PMID: 24274622
We generated transgenic mice expressing bovine cellular prion protein (PrP(C)) with a leucine substitution at codon 113 (113L). This protein is homologous to human protein with mutation 102L, and its...