Josue de Moraes
Overview
Explore the profile of Josue de Moraes including associated specialties, affiliations and a list of published articles.
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91
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961
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Recent Articles
11.
Roquini D, Lemes B, Kreutz A, Spoladore S, Amaro M, Lopes F, et al.
ACS Omega
. 2024 Jul;
9(28):31159-31165.
PMID: 39035884
Infections caused by parasitic helminths pose significant health concerns for both humans and animals. The limited efficacy of existing drugs underscores the urgent need for novel anthelmintic agents. Given the...
12.
Cogo R, Pavani T, Mengarda A, Cajas R, Teixeira T, Fukui-Silva L, et al.
ACS Omega
. 2024 Jun;
9(23):25356-25369.
PMID: 38882094
Schistosomiasis is a neglected disease of poverty that affects over 200 million people worldwide and relies on a single drug for therapy. The cathepsin B1 cysteine protease (SmCB1) of has...
13.
Cajas R, Santos S, Espirito-Santo M, Garedaghi Y, de Moraes J
Antimicrob Agents Chemother
. 2024 May;
68(7):e0011424.
PMID: 38780260
Schistosomiasis, a widespread parasitic disease caused by the blood fluke of the genus , affects over 230 million people, primarily in developing countries. Praziquantel, the sole drug currently approved for...
14.
Oliveira L, Camilo F, Soares M, Cajas R, Cirino M, de Moraes J, et al.
Chem Biodivers
. 2024 Jan;
21(3):e202301929.
PMID: 38278761
Schistosomiasis is a major neglected disease that imposes a substantial worldwide health burden, affecting approximately 250 million people globally. As praziquantel is the only available drug to treat schistosomiasis, there...
15.
Pavani T, Cirino M, Teixeira T, de Moraes J, G G Rando D
Sci Rep
. 2023 Nov;
13(1):19735.
PMID: 37957227
The chemical classes of semicarbazones, thiosemicarbazones, and hydrazones are present in various compounds, each demonstrating diverse biological activities. Extensive studies have revealed their potential as schistosomicidal agents. Thiosemicarbazones, in particular,...
16.
Moreira-Filho J, Neves B, Cajas R, de Moraes J, Andrade C
Future Med Chem
. 2023 Nov;
15(22):2033-2050.
PMID: 37937522
The impact of schistosomiasis, which affects over 230 million people, emphasizes the urgency of developing new antischistosomal drugs. Artificial intelligence is vital in accelerating the drug discovery process. We developed...
17.
Rocha V, Cajas R, Andrade-de-Siqueira A, Almeida R, Godoy-Silva J, Goncalves M, et al.
ACS Omega
. 2023 Nov;
8(43):40890-40897.
PMID: 37929107
Schistosomiasis, a parasitic disease affecting nearly 250 million individuals globally, poses a significant health challenge. With praziquantel being the sole available treatment and its limited efficacy in early stage infections,...
18.
Roquini V, Mengarda A, Cajas R, Martins-da-Silva M, Godoy-Silva J, Santos G, et al.
Microbiol Spectr
. 2023 Jul;
11(4):e0139323.
PMID: 37409934
Schistosomiasis is a parasitic disease that afflicts approximately 250 million people worldwide. There is an urgent demand for new antiparasitic agents because praziquantel, the only drug available for the treatment...
19.
20.
de Souza Costa D, Leal C, Cajas R, Gazolla M, Silva L, Aleixo de Carvalho L, et al.
J Ethnopharmacol
. 2023 May;
313:116607.
PMID: 37149066
Ethnopharmacological Relevance: Roots of Pothomorphe umbellata (L.) Miq. are used in traditional medicine of Africa and South America for the treatment of malaria and helminthiasis. However, neither P. umbellata nor...