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Josien C van Wolfswinkel

Explore the profile of Josien C van Wolfswinkel including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Carmell M, Dokshin G, Skaletsky H, Hu Y, van Wolfswinkel J, Igarashi K, et al.
Elife . 2016 Nov; 5. PMID: 27718356
The advent of sexual reproduction and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukaryotic evolution. We report an ancient family of GCNA (germ cell...
12.
van Wolfswinkel J, Wagner D, Reddien P
Cell Stem Cell . 2014 Jul; 15(3):326-339. PMID: 25017721
Planarians are flatworms capable of regenerating any missing body region. This capacity is mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells. Although population-based studies have revealed...
13.
van Wolfswinkel J
Integr Comp Biol . 2014 Jun; 54(4):700-13. PMID: 24948137
PIWI proteins are well known for their roles in the animal germline. They are essential for germline development and maintenance, and together with their binding partners, the piRNAs, they mediate...
14.
Srivastava M, Mazza-Curll K, van Wolfswinkel J, Reddien P
Curr Biol . 2014 Apr; 24(10):1107-13. PMID: 24768051
Whole-body regeneration is widespread in the Metazoa, yet little is known about how underlying molecular mechanisms compare across phyla. Acoels are an enigmatic phylum of invertebrate worms that can be...
15.
Phillips C, Montgomery B, Breen P, Roovers E, Rim Y, Ohsumi T, et al.
Curr Biol . 2014 Apr; 24(8):839-44. PMID: 24684932
More than 2,000 C. elegans genes are targeted for RNA silencing by the mutator complex, a specialized small interfering RNA (siRNA) amplification module which is nucleated by the Q/N-rich protein...
16.
Kamminga L, van Wolfswinkel J, Luteijn M, Kaaij L, Bagijn M, Sapetschnig A, et al.
PLoS Genet . 2012 Jul; 8(7):e1002702. PMID: 22829772
RNA interference (RNAi)-related pathways affect gene activity by sequence-specific recruitment of Ago proteins to mRNA target molecules. The sequence specificity of this process stems from small RNA (sRNA) co-factors bound...
17.
van Wolfswinkel J, Ketting R
J Cell Sci . 2010 May; 123(Pt 11):1825-39. PMID: 20484663
Small non-coding RNAs make up much of the RNA content of a cell and have the potential to regulate gene expression on many different levels. Initial discoveries in the 1990s...
18.
van Wolfswinkel J, Claycomb J, Batista P, Mello C, Berezikov E, Ketting R
Cell . 2009 Oct; 139(1):135-48. PMID: 19804759
We have studied the function of a conserved germline-specific nucleotidyltransferase protein, CDE-1, in RNAi and chromosome segregation in C. elegans. CDE-1 localizes specifically to mitotic chromosomes in embryos. This localization...
19.
Claycomb J, Batista P, Pang K, Gu W, Vasale J, van Wolfswinkel J, et al.
Cell . 2009 Oct; 139(1):123-34. PMID: 19804758
RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicase DRH-3,...
20.
Van Och F, Van Loveren H, van Wolfswinkel J, Machielsen A, Vandebriel R
Toxicology . 2005 Apr; 210(2-3):95-109. PMID: 15840424
Assessment of allergenic potency of low molecular weight compounds is generally performed using animal models, such as the guinea pig maximisation test and the murine local lymph node assay (LLNA)....