Josiah Sliz
Overview
Explore the profile of Josiah Sliz including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
497
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Recent Articles
1.
Varone A, Nguyen J, Leng L, Barrile R, Sliz J, Lucchesi C, et al.
Biomaterials
. 2021 Jun;
275:120957.
PMID: 34130145
Successful translation of in vivo experimental data to human patients is an unmet need and a bottleneck in the development of effective therapeutics. Organ-on-Chip technology aims to address this need...
2.
Novak R, Ingram M, Marquez S, Das D, Delahanty A, Herland A, et al.
Nat Biomed Eng
. 2020 Jan;
4(4):407-420.
PMID: 31988458
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom software and...
3.
Kasendra M, Luc R, Yin J, Manatakis D, Kulkarni G, Lucchesi C, et al.
Elife
. 2020 Jan;
9.
PMID: 31933478
Induction of intestinal drug metabolizing enzymes can complicate the development of new drugs, owing to the potential to cause drug-drug interactions (DDIs) leading to changes in pharmacokinetics, safety and efficacy....
4.
Jang K, Otieno M, Ronxhi J, Lim H, Ewart L, Kodella K, et al.
Sci Transl Med
. 2019 Nov;
11(517).
PMID: 31694927
Nonclinical rodent and nonrodent toxicity models used to support clinical trials of candidate drugs may produce discordant results or fail to predict complications in humans, contributing to drug failures in...
5.
Davidson P, Sliz J, Isermann P, Denais C, Lammerding J
Integr Biol (Camb)
. 2015 Nov;
7(12):1534-46.
PMID: 26549481
The ability of cells to migrate through tissues and interstitial spaces is an essential factor during development and tissue homeostasis, immune cell mobility, and in various human diseases. Deformation of...