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Joshua Klein

Explore the profile of Joshua Klein including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 35
Citations 433
Followers 0
Related Specialties
Biochemistry
Critical Care
General Surgery
Top 10 Co-Authors
Kartik Prabhakaran
Joseph Zaia
Bardiya Zangbar
Aryan Rafieezadeh
Ilya Shnaydman
Jorge Con
Peter Rhee
Matthew Bronstein
Rifat Latifi
Abbas Smiley
Published In
Trauma Surg Acute Care Open
J Proteome Res
Anal Chem
Nat Commun
Mol Cell Proteomics
Affiliations
Soon will be listed here.
Recent Articles
1.
Identification of Unexpected Pathomechanisms Underlying the Human Usher Syndrome
Wolfrum U, Linnert J, Guler B, Klein J, Fritze J, Wenck N, et al.
Adv Exp Med Biol . 2025 Feb; 1468:171-175. PMID: 39930191
Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness, characterized by inner ear defects and late-onset vision loss. USH is a complex genetic disorder, clinically and genetically...
2.
Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs
Kiraly P, Klein J, Seitz I, Reichel F, Peters T, Ardan T, et al.
Invest Ophthalmol Vis Sci . 2025 Jan; 66(1):48. PMID: 39836403
Purpose: This study aimed to evaluate early-phase safety of subretinal application of AAVanc80.CAG.USH1Ca1 (OT_USH_101) in wild-type (WT) pigs, examining the effects of a vehicle control, low dose, and high dose....
3.
Extracorporeal membrane oxygenation is associated with decreased mortality in non-acute respiratory distress syndrome patients following severe blunt thoracic trauma
Zangbar B, Rafieezadeh A, Prabhakaran K, Jose A, Shnaydman I, Bronstein M, et al.
J Trauma Acute Care Surg . 2025 Jan; PMID: 39836095
Background: Extracorporeal membrane oxygenation (ECMO) has emerged as a critical intervention in the management of patients with trauma-induced cardiorespiratory failure. This study aims to compare outcomes in patients with severe...
4.
Robotic versus Laparoscopic Emergency and Acute Care Surgery: Redefining Novelty (RLEARN): feasibility and benefit of robotic cholecystectomy for acute cholecystitis at a level 1 trauma center
Klein J, Lemma M, Prabhakaran K, Rafieezadeh A, Kirsch J, Rodriguez G, et al.
Trauma Surg Acute Care Open . 2024 Dec; 9(1):e001522. PMID: 39737144
Background: This study aims to compare outcomes of robotic cholecystectomy (RC) versus laparoscopic cholecystectomy (LC) in the setting of a level 1 trauma center. Methods: We performed a retrospective study...
5.
Obesity portends an increased risk of thromboembolic events in severely injured geriatric trauma, a retrospective study
Zangbar B, Lin N, Rafieezadeh A, Kirsch J, Shnaydman I, Eckenberg L, et al.
Am J Surg . 2024 Dec; 240():116139. PMID: 39671969
Background: Obesity is a known risk factor for thromboembolic complications in trauma patients. The aim of our study is to evaluate the prevalence of thrombotic complications in obese geriatric patients....
6.
The Proteomics Standards Initiative Standardized Formats for Spectral Libraries and Fragment Ion Peak Annotations: mzSpecLib and mzPAF
Klein J, Lam H, Mak T, Bittremieux W, Perez-Riverol Y, Gabriels R, et al.
Anal Chem . 2024 Nov; 96(46):18491-18501. PMID: 39514576
Mass spectral libraries are collections of reference spectra, usually associated with specific analytes from which the spectra were generated, that are used for further downstream analysis of new spectra. There...
7.
Step-by-step roadmap to building a robotic acute care surgery program (RACSP) in a level I trauma center: outcomes and lessons learned after 1-year implementation
Jose A, Rafieezadeh A, Zangbar B, Klein J, Kirsch J, Shnaydman I, et al.
Trauma Surg Acute Care Open . 2024 Jul; 9(1):e001449. PMID: 39077748
Minimally invasive surgical techniques have demonstrated superior outcomes across various elective procedures. Laparoscopic surgery (LS) is established in general surgery with laparoscopic operations for acute appendicitis and cholecystitis being the...
8.
Expanding N-glycopeptide identifications by modeling fragmentation, elution, and glycome connectivity
Klein J, Carvalho L, Zaia J
Nat Commun . 2024 Jul; 15(1):6168. PMID: 39039063
Accurate glycopeptide identification in mass spectrometry-based glycoproteomics is a challenging problem at scale. Recent innovation has been made in increasing the scope and accuracy of glycopeptide identifications, with more precise...
9.
mzIdentML 1.3.0 - Essential progress on the support of crosslinking and other identifications based on multiple spectra
Combe C, Kolbowski L, Fischer L, Koskinen V, Klein J, Leitner A, et al.
Proteomics . 2024 Jul; 24(17):e2300385. PMID: 39001627
The mzIdentML data format, originally developed by the Proteomics Standards Initiative in 2011, is the open XML data standard for peptide and protein identification results coming from mass spectrometry. We...
10.
CT in musculoskeletal imaging: still helpful and for what?
Carrino J, Ibad H, Lin Y, Ghotbi E, Klein J, Demehri S, et al.
Skeletal Radiol . 2024 Jul; 53(9):1711-1725. PMID: 38969781
Computed tomography (CT) is a common modality employed for musculoskeletal imaging. Conventional CT techniques are useful for the assessment of trauma in detection, characterization and surgical planning of complex fractures....