Joshua J Wang
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Explore the profile of Joshua J Wang including associated specialties, affiliations and a list of published articles.
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1723
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Recent Articles
1.
Yera M, Wang J, Zhang S
STAR Protoc
. 2025 Jan;
6(1):103595.
PMID: 39854204
Defects in retinal metabolism have been linked to the onset and progression of various retinal diseases. Herein, we provide a protocol for measuring bioenergetics in dissociated mouse retinal photoreceptors. We...
2.
Wang J, Lai D, Wang J, Zhang S
PLoS One
. 2024 May;
19(5):e0303010.
PMID: 38748682
Diabetic Retinopathy (DR) is the leading cause of vision loss in working-age adults. The hallmark features of DR include vascular leakage, capillary loss, retinal ischemia, and aberrant neovascularization. Although the...
3.
Essential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy
McLaughlin T, Wang G, Medina A, Perkins J, Nihlawi R, Seyfried D, et al.
Invest Ophthalmol Vis Sci
. 2023 Nov;
64(14):40.
PMID: 38015176
Purpose: Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults characterized by retinal dysfunction and neurovascular degeneration. We previously reported that deletion of X-box binding protein 1...
4.
McLaughlin T, Wang J, Jia L, Wu F, Wang Y, Wang J, et al.
Cells
. 2023 Jun;
12(12).
PMID: 37371028
p58 is a multifaceted endoplasmic reticulum (ER) chaperone and a regulator of eIF2α kinases involved in a wide range of cellular processes including protein synthesis, ER stress response, and macrophage-mediated...
5.
Tang X, Wang J, Abboud H, Chen Y, Wang J, Zhang S
Diabetes
. 2022 Nov;
72(1):112-125.
PMID: 36321974
NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in retinal endothelial cells (ECs) and is upregulated under hyperglycemic and hypoxic conditions. However, the role of...
6.
Wang J, Park K, Dhimal N, Shen S, Tang X, Qu J, et al.
Cells
. 2022 Sep;
11(18).
PMID: 36139394
The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium signaling, bioenergetics,...
7.
McLaughlin T, Medina A, Perkins J, Yera M, Wang J, Zhang S
Mol Neurodegener
. 2022 Mar;
17(1):25.
PMID: 35346303
Background: The retina, as part of the central nervous system (CNS) with limited capacity for self-reparation and regeneration in mammals, is under cumulative environmental stress due to high-energy demands and...
8.
Hanineva A, Park K, Wang J, Deangelis M, Farkas M, Zhang S
Neural Regen Res
. 2022 Feb;
17(9):1875-1880.
PMID: 35142661
Retinal disorders are a group of ocular diseases whose onset is associated with a number of aberrant molecular and cellular processes or physical damages that affect retinal structure and function...
9.
Tang X, Wang J, Wang J, Abboud H, Chen Y, Zhang S
Angiogenesis
. 2020 Nov;
24(2):363-377.
PMID: 33201372
NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidases playing an important role in many biological processes. Previously we have shown that Nox4 is highly expressed in retinal...
10.
McLaughlin T, Siddiqi M, Wang J, Zhang S
J Clin Med
. 2019 Jun;
8(6).
PMID: 31242599
Retinal neuronal injury and degeneration is one of the primary manifestations of diabetic retinopathy, a leading cause of vision loss in working age adults. In pathological conditions, including diabetes and...