Joseph Tomaszewski
Overview
Explore the profile of Joseph Tomaszewski including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
372
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0
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Recent Articles
1.
Burton J, Mazcko C, LeBlanc A, Covey J, Ji J, Kinders R, et al.
Clin Cancer Res
. 2018 Aug;
24(23):5830-5840.
PMID: 30061364
Purpose: Only one chemical class of topoisomerase I (TOP1) inhibitors is FDA approved, the camptothecins with irinotecan and topotecan widely used. Because of their limitations (chemical instability, drug efflux-mediated resistance,...
2.
Speranza G, Anderson L, Chen A, Do K, Eugeni M, Weil M, et al.
Invest New Drugs
. 2017 Aug;
36(2):230-239.
PMID: 28808818
Background Molecular chaperone targeting has shown promise as a therapeutic approach in human cancers of various histologies and genetic backgrounds. The purine-scaffold inhibitor PU-H71 (NSC 750424), selective for Hsp90 in...
3.
Kummar S, Chen A, Gutierrez M, Pfister T, Wang L, Redon C, et al.
Cancer Chemother Pharmacol
. 2016 May;
78(1):73-81.
PMID: 27169793
Purpose: Indenoisoquinolines are non-camptothecin topoisomerase I (TopI) inhibitors that overcome the limitations of camptothecins: chemical instability and camptothecin resistance. Two dosing schedules of the novel indenoisoquinoline, indotecan (LMP400), were evaluated...
4.
Kummar S, Chen H, Wright J, Holbeck S, Davis Millin M, Tomaszewski J, et al.
Nat Rev Drug Discov
. 2010 Oct;
9(11):843-56.
PMID: 21031001
The rapid development of new therapeutic agents that target specific molecular pathways involved in tumour cell proliferation provides an unprecedented opportunity to achieve a much higher degree of biochemical specificity...
5.
Kinders R, Hollingshead M, Lawrence S, Ji J, Tabb B, Bonner W, et al.
Clin Cancer Res
. 2010 Oct;
16(22):5447-57.
PMID: 20924131
Purpose: Phosphorylated histone H2AX (γH2AX) serves as a biomarker for formation of DNA double-strand break repair complexes. A quantitative pharmacodynamic immunofluorescence assay for γH2AX was developed, validated, and tested in...
6.
Rausch L, Green C, Steinmetz K, LeValley S, Catz P, Zaveri N, et al.
Cancer Chemother Pharmacol
. 2010 Aug;
67(6):1341-52.
PMID: 20737149
Purpose: SR16157 is a novel dual-acting inhibitor of estrogen action that irreversibly inhibits the estrogen biosynthetic enzyme steroid sulfatase (STS) and releases the selective estrogen receptor modulator SR16137, which blocks...
7.
Jia L, Noker P, Piazza G, Leuschner C, Hansel W, Gorman G, et al.
J Pharm Pharmacol
. 2008 Oct;
60(11):1441-8.
PMID: 18957164
Phor21-betaCG(ala), a 36-amino acid peptide comprised of a lytic peptide (Phor21) conjugated to a modified 15-amino acid segment of the beta-chain of chorionic gonadotropin (betaCG(ala)), selectively kills cancer cells that...
8.
Jia L, Schweikart K, Tomaszewski J, Page J, Noker P, Buhrow S, et al.
Food Chem Toxicol
. 2007 Sep;
46(1):203-11.
PMID: 17868966
1-methyl-d-tryptophan (D-1MT) reverses the immunosuppressive effect of indoleamine 2,3-dioxygenase (IDO), and it is currently being developed both as a vaccine adjuvant and as an immunotherapeutic agent for combination with chemotherapy....
9.
Page J, Tian B, Schweikart K, Tomaszewski J, Harris R, Broadt T, et al.
Am J Obstet Gynecol
. 2007 Apr;
196(4):389.e1-9.
PMID: 17403430
Objective: The purpose of this study was to evaluate the biodistribution and toxicity of the tropism-modified infectivity-enhanced conditionally replicative adenovirus, Ad5-delta24-arginine-glycine-aspartate (RGD). Study Design: Cohorts of cotton rats were treated...
10.
Fry T, Moniuszko M, Creekmore S, Donohue S, Douek D, Giardina S, et al.
Blood
. 2002 Nov;
101(6):2294-9.
PMID: 12411295
Interleukin-7 (IL-7) is important for thymopoiesis in mice and humans because IL-7 receptor alpha (IL-7Ralpha) mutations result in a severe combined immunodeficiency phenotype with severe thymic hypoplasia. Recent evidence has...