Joseph R Missert
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Explore the profile of Joseph R Missert including associated specialties, affiliations and a list of published articles.
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321
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Recent Articles
1.
Dukh M, Cacaccio J, Durrani F, Kumar I, Watson R, Tabaczynski W, et al.
Eur J Med Chem Rep
. 2022 Dec;
5.
PMID: 36568335
To investigate the impact of mono- and di-β-galactose moieties in tumor uptake and photodynamic therapy (PDT) efficacy, HPPH [3-(1'-hexyloxy)ethyl-3-devinylpyropheophorobide-a], the meso pyropheophorbide-a [3-ethyl-3-devinyl-pyropheophorbide-a], and the corresponding 20-benzoic acid analogs were...
2.
Cheruku R, Turowski S, Durrani F, Tabaczynski W, Cacaccio J, Missert J, et al.
J Med Chem
. 2022 Jun;
65(13):9267-9280.
PMID: 35763292
3-(1'-Hexyloxyethyl)-3-devinylpyropheophorbide-a (HPPH or Photochlor), a tumor-avid chlorophyll derivative currently undergoing human clinical trials, was conjugated with mono-, di-, and tri-Gd(III)tetraxetan (DOTA) moieties. The T/T relaxivity and PDT efficacy of these...
3.
Cacaccio J, Durrani F, Missert J, Pandey R
Biomedicines
. 2022 Apr;
10(4).
PMID: 35453607
We have previously shown that a radioactive (I)-analog of methyl 3-(1'-(iodobexyloxy) ethyl-3-devinylpyropheophorbide-a (PET-ONCO), derived from chlorophyll-a can be used for positron emission tomography (PET) imaging of a variety of tumors,...
4.
Cheruku R, Tracy E, Tabaczynski W, Missert J, Baumann H, Pandey R
J Med Chem
. 2021 Apr;
64(8):4787-4809.
PMID: 33822622
To investigate the importance of the chirality and precise structure at position 3(1') of pyropheophorbide-a for tumor cell specificity and photodynamic therapy (PDT), a series of photosensitizers (PSs) was synthesized:...
5.
Cheruku R, Cacaccio J, Durrani F, Tabaczynski W, Watson R, Siters K, et al.
J Med Chem
. 2021 Jan;
64(1):741-767.
PMID: 33400524
Erlotinib was covalently linked to 3-(1'-hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) and structurally related chlorins and bacteriochlorins at different positions of the tetrapyrrole ring. The functional consequence of each modification was determined by quantifying...
6.
Marko A, Borah B, Siters K, Missert J, Gupta A, Pera P, et al.
Biomolecules
. 2020 Dec;
10(12).
PMID: 33317162
This report presents the synthesis and folate receptor target-specificity of amino-functionalized polyacrylamide nanoparticles (AFPAA NPs) for near-infrared (NIR) fluorescence imaging of cancer. For the synthesis of desired nano-constructs, the AFPAA...
7.
Zhang S, Cheruku R, Dukh M, Tabaczynski W, Patel N, White 3rd W, et al.
ChemMedChem
. 2020 Sep;
15(21):2058-2070.
PMID: 32916033
3-(1'-Hexyloxyethyl)-3-devinyl-pyropheophorbide-a (HPPH or Photochlor), a tumor-avid chlorophyll-a derivative currently undergoing human clinical trials, was conjugated at various peripheral positions (position-17 or 20) of HPPH with either Gd(III)-aminobenzyl-DTPA (Gd(III) DTPA) or...
8.
Srivatsan A, Pera P, Joshi P, Marko A, Durrani F, Missert J, et al.
J Photochem Photobiol B
. 2020 Aug;
211:111998.
PMID: 32862090
Herein we report the positron emission tomography (PET) imaging potential of a I-labeled radiopharmaceutical (PET-ONCO). In tumored mice, it shows high uptake in a variety of tumors: brain (GL261, U87),...
9.
Cacaccio J, Durrani F, Cheruku R, Borah B, Ethirajan M, Tabaczynski W, et al.
Photochem Photobiol
. 2019 Nov;
96(3):625-635.
PMID: 31738460
To determine the impact of delivery vehicles in photosensitizing efficacy of HPPH, a hydrophobic photosensitizer was dissolved in various formulations: 1% Tween 80/5% dextrose, Pluronic P-123 and Pluronic F-127 in...
10.
Marko A, Dukh M, Patel N, Missert J, Ohulchanskyy T, Tabaczynski W, et al.
ChemMedChem
. 2019 Jul;
14(16):1503-1513.
PMID: 31343840
Herein we report the synthesis, photophysical properties, positron emission tomography (PET) imaging and photodynamic therapy (PDT) efficacy of methyl 3-(1'-m-iodobenzyloxy)ethyl-3-devinyl-verdin 4 (with or without the I isotope). The PET imaging...