Joseph R A Kincaid
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Explore the profile of Joseph R A Kincaid including associated specialties, affiliations and a list of published articles.
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7
Citations
88
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Recent Articles
1.
Kincaid J, Wong M, Akporji N, Gallou F, Fialho D, Lipshutz B
J Am Chem Soc
. 2023 Feb;
PMID: 36753354
Savie is a biodegradable surfactant derived from vitamin E and polysarcosine (PSar) developed for use in organic synthesis in recyclable water. This includes homogeneous catalysis (including examples employing only ppm...
2.
Kavthe R, Kincaid J, Lipshutz B
ACS Sustain Chem Eng
. 2022 Dec;
10(50):16896-16902.
PMID: 36569493
An 11-step, 8-pot synthesis of the antimalarial drug tafenoquine succinate was achieved in 42% overall yield using commercially available starting materials. Compared to the previous manufacturing processes that utilize environmentally...
3.
Caravez J, Iyer K, Kavthe R, Kincaid J, Lipshutz B
Org Lett
. 2022 Dec;
24(49):9049-9053.
PMID: 36475781
A newly devised route to the Pfizer drug nirmatrelvir is reported that reduces the overall sequence to a 1-pot process and relies on a commercially available, green coupling reagent, T3P....
4.
Kincaid J, Caravez J, Iyer K, Kavthe R, Fleck N, Aue D, et al.
Commun Chem
. 2022 Dec;
5(1):156.
PMID: 36465589
Pfizer's drug for the treatment of patients infected with COVID-19, Paxlovid, contains most notably nirmatrelvir, along with ritonavir. Worldwide demand is projected to be in the hundreds of metric tons...
5.
Kincaid J, Kavthe R, Caravez J, Takale B, Thakore R, Lipshutz B
Org Lett
. 2022 May;
24(18):3342-3346.
PMID: 35504038
Two routes to the antimalarial drug Pyronaridine are described. The first is a linear sequence that includes a two-step, one-pot transformation in an aqueous surfactant medium, leading to an overall...
6.
Cortes-Clerget M, Yu J, Kincaid J, Walde P, Gallou F, Lipshutz B
Chem Sci
. 2021 Jun;
12(12):4237-4266.
PMID: 34163692
A review presenting water as the logical reaction medium for the future of organic chemistry. A discussion is offered that covers both the "on water" and "in water" phenomena, and...
7.
Wood A, Cortes-Clerget M, Kincaid J, Akkachairin B, Singhania V, Gallou F, et al.
Angew Chem Int Ed Engl
. 2020 Jun;
59(40):17587-17593.
PMID: 32579762
Mild mono- and di-hydrodehalogenative reductions of gem-dibromocyclopropanes are described, providing an easy and green approach towards the synthesis of cyclopropanes. The methodology utilizes 0.5-5 mol % TMPhen-nickel as the catalyst,...