Joseph Nasser
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Explore the profile of Joseph Nasser including associated specialties, affiliations and a list of published articles.
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16
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1387
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Recent Articles
1.
Nasser J, Nam K, Gunawardena J
bioRxiv
. 2024 Dec;
PMID: 39677755
Enhancers are discrete DNA elements that regulate the expression of eukaryotic genes. They are important not only for their regulatory function, but also as loci that are frequently associated with...
2.
Guckelberger P, Doughty B, Munson G, Rao S, Tan Y, Cai X, et al.
bioRxiv
. 2024 Jul;
PMID: 39026740
Enhancers are key drivers of gene regulation thought to act via 3D physical interactions with the promoters of their target genes. However, genome-wide depletions of architectural proteins such as cohesin...
3.
Gschwind A, Mualim K, Karbalayghareh A, Sheth M, Dey K, Jagoda E, et al.
bioRxiv
. 2023 Nov;
PMID: 38014075
Identifying transcriptional enhancers and their target genes is essential for understanding gene regulation and the impact of human genetic variation on disease. Here we create and evaluate a resource of...
4.
Weeks E, Ulirsch J, Cheng N, Trippe B, Fine R, Miao J, et al.
Nat Genet
. 2023 Jul;
55(8):1267-1276.
PMID: 37443254
Genome-wide association studies (GWASs) are a valuable tool for understanding the biology of complex human traits and diseases, but associated variants rarely point directly to causal genes. In the present...
5.
Moonen J, Chappell J, Shi M, Shinohara T, Li D, Mumbach M, et al.
Nat Commun
. 2022 Aug;
13(1):4941.
PMID: 35999210
Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote this...
6.
Dey K, Gazal S, van de Geijn B, Kim S, Nasser J, Engreitz J, et al.
Cell Genom
. 2022 Jul;
2(7).
PMID: 35873673
We assess contributions to autoimmune disease of genes whose regulation is driven by enhancer regions (enhancer-related) and genes that regulate other genes in (candidate master-regulator). We link these genes to...
7.
Gazal S, Weissbrod O, Hormozdiari F, Dey K, Nasser J, Jagadeesh K, et al.
Nat Genet
. 2022 Jun;
54(6):827-836.
PMID: 35668300
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking strategies have been developed to link regulatory SNPs to the...
8.
Bergman D, Jones T, Liu V, Ray J, Jagoda E, Siraj L, et al.
Nature
. 2022 May;
607(7917):176-184.
PMID: 35594906
Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters. A proposed model for this specificity is that promoters have sequence-encoded preferences for certain...
9.
Nasser J, Bergman D, Fulco C, Guckelberger P, Doughty B, Patwardhan T, et al.
Nature
. 2021 Apr;
593(7858):238-243.
PMID: 33828297
Genome-wide association studies (GWAS) have identified thousands of noncoding loci that are associated with human diseases and complex traits, each of which could reveal insights into the mechanisms of disease....
10.
Bick A, Weinstock J, Nandakumar S, Fulco C, Bao E, Zekavat S, et al.
Nature
. 2021 Mar;
591(7851):E27.
PMID: 33707633
No abstract available.