Joseph M Martinez
Overview
Explore the profile of Joseph M Martinez including associated specialties, affiliations and a list of published articles.
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9
Citations
152
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0
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Recent Articles
1.
Martinez J, Shen A, Xu B, Jovanovic A, de Chabot J, Zhang J, et al.
Sci Signal
. 2023 Mar;
16(778):eade3380.
PMID: 36976866
G protein-coupled receptors (GPCRs) promote the expression of immediate early genes required for learning and memory. Here, we showed that β-adrenergic receptor (βAR) stimulation induced the nuclear export of phosphodiesterase...
2.
Shams S, Martinez J, Dawson J, Flores J, Gabriel M, Garcia G, et al.
Front Pharmacol
. 2021 Jun;
12:680043.
PMID: 34122106
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many...
3.
Shen A, Chen D, Kaur M, Bartels P, Xu B, Shi Q, et al.
Elife
. 2019 Oct;
8.
PMID: 31609201
G protein-coupled receptors (GPCRs) transduce pleiotropic intracellular signals in mammalian cells. Here, we report neuronal excitability of β-blockers carvedilol and alprenolol at clinically relevant nanomolar concentrations. Carvedilol and alprenolol activate...
4.
Bergeson S, Blanton H, Martinez J, Curtis D, Sherfey C, Seegmiller B, et al.
Alcohol Clin Exp Res
. 2016 Nov;
40(12):2506-2515.
PMID: 27862022
Background: Physicians have long reported that patients with chronic pain show higher tendencies for alcohol use disorder (AUD), and AUD patients appear to have higher pain sensitivities. The goal of...
5.
Martinez J, Groot J, Curtis D, Allison C, Marquardt P, Holmes A, et al.
Alcohol Clin Exp Res
. 2016 Nov;
40(12):2499-2505.
PMID: 27862011
Background: Alcohol use disorder (AUD) is a spectrum disorder characterized by mild to severe symptoms, including potential withdrawal signs upon cessation of consumption. Approximately five hundred thousand patients with AUD...
6.
Syapin P, Martinez J, Curtis D, Marquardt P, Allison C, Groot J, et al.
Alcohol Clin Exp Res
. 2016 Nov;
40(12):2482-2490.
PMID: 27859416
Background: New pharmacotherapies to treat alcohol use disorders (AUD) are needed. Given the complex nature of AUD, there likely exist multiple novel drug targets. We, and others, have shown that...
7.
Harris J, Martinez J, Grozdanov P, Bergeson S, Grammas P, MacDonald C
PLoS One
. 2016 Nov;
11(11):e0165976.
PMID: 27812195
Polyadenylation is an essential mechanism for the processing of mRNA 3' ends. CstF-64 (the 64,000 Mr subunit of the cleavage stimulation factor; gene symbol Cstf2) is an RNA-binding protein that...
8.
Grammas P, Martinez J
J Alzheimers Dis
. 2014 Aug;
42 Suppl 4:S537-44.
PMID: 25079808
The Alzheimer's disease (AD) epidemic proceeds unabated. Estimates suggest 5.4 million Americans and 36 million people worldwide have AD. No single mechanism or pathologic mediator can account for AD progression....
9.
Sanchez A, Tripathy D, Yin X, Luo J, Martinez J, Grammas P
J Neuroinflammation
. 2013 Jul;
10:93.
PMID: 23880112
Background: Angiogenesis is tightly linked to inflammation and cancer. Regulation of angiogenesis is mediated primarily through activation of receptor tyrosine kinases, thus kinase inhibitors represent a new paradigm in anti-cancer...