Joseph Locker
Overview
Explore the profile of Joseph Locker including associated specialties, affiliations and a list of published articles.
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62
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1662
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Recent Articles
1.
Bano S, Copeland M, Stoops J, Orr A, Jain S, Paranjpe S, et al.
Cell Mol Gastroenterol Hepatol
. 2024 Jul;
18(4):101380.
PMID: 39038606
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disorder, with no approved treatment. Our previous work demonstrated the efficacy of a pan-ErbB...
2.
Mekala S, Rai R, Reed S, Bowen B, Michalopoulos G, Locker J, et al.
Cells
. 2024 Apr;
13(7.
PMID: 38607090
Background/aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the effect of novel, highly specific small-molecule-based...
3.
Melis M, Marino R, Tian J, Johnson C, Sethi R, Oertel M, et al.
Cell Mol Gastroenterol Hepatol
. 2023 Nov;
17(3):453-479.
PMID: 37993018
Background & Aims: HNF4α, a master regulator of liver development and the mature hepatocyte phenotype, is down-regulated in chronic and inflammatory liver disease. We used contemporary transcriptomics and epigenomics to...
4.
Chen T, Dalton G, Oh S, Maeso-Diaz R, Du K, Meyers R, et al.
Cell Mol Gastroenterol Hepatol
. 2022 Dec;
15(4):949-970.
PMID: 36535507
Background & Aims: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration....
5.
Roy N, Alencastro F, Roseman B, Wilson S, Delgado E, May M, et al.
Am J Pathol
. 2022 Jun;
192(9):1259-1281.
PMID: 35718058
Nonalcoholic fatty liver disease (NAFLD) is an epidemic affecting 30% of the US population. It is characterized by insulin resistance, and by defective lipid metabolism and mitochondrial dysfunction in the...
6.
Tian J, Locker J
Adv Exp Med Biol
. 2022 May;
1360:87-99.
PMID: 35505164
Injury and growth stimulation both remarkably increase the hepatic expression of Gadd45β. This contrasts with expression in liver cancer, where promoter methylation frequently silences Gadd45β, due to a suppressive function...
7.
Koral K, Bhushan B, Orr A, Stoops J, Bowen W, Copeland M, et al.
Am J Pathol
. 2022 Apr;
192(6):887-903.
PMID: 35390317
Activation of constitutive androstane receptor (CAR) transcription factor by xenobiotics promotes hepatocellular proliferation, promotes hypertrophy without liver injury, and induces drug metabolism genes. Previous work demonstrated that lymphocyte-specific protein-1 (LSP1),...
8.
Kouwenhoven W, Von Oerthel L, Gruppilo M, Tian J, Wagemans C, Houwers I, et al.
Int J Mol Sci
. 2021 Dec;
22(23).
PMID: 34884468
is a member of the NK homeobox family and resembles both in homology and expression pattern. However, while is required for development of serotonergic neurons, the role of in the...
9.
Liao J, Coffman K, Locker J, Padiath Q, Nmezi B, Filipink R, et al.
Mol Genet Genomic Med
. 2021 Mar;
9(4):e1647.
PMID: 33666368
Background: Benign hereditary chorea (BHC) is an autosomal dominant disorder characterized by early-onset non-progressive involuntary movements. Although NKX2-1 mutations or deletions are the cause of BHC, some BHC families do...
10.
Bhushan B, Molina L, Koral K, Stoops J, Mars W, Banerjee S, et al.
Hepatology
. 2020 Aug;
73(5):2005-2022.
PMID: 32794202
Background And Aims: Constitutive androstane receptor (CAR) agonists, such as 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), are known to cause robust hepatocyte proliferation and hepatomegaly in mice along with induction of drug...