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Joseph Kozole

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Articles 14
Citations 154
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Recent Articles
1.
Jimenez-Duran G, Kozole J, Peltier-Heap R, Dickinson E, Kwiatkowski C, Zappacosta F, et al.
Front Immunol . 2022 Oct; 13:918551. PMID: 36248901
The complement system is an ancient and critical part of innate immunity. Recent studies have highlighted novel roles of complement beyond lysis of invading pathogens with implications in regulating the...
2.
Belov A, Kozole J, Bean M, Machutta C, Zhang G, Gao E, et al.
Anal Chem . 2020 Sep; 92(20):13847-13854. PMID: 32970424
Drug discovery usually begins with a high-throughput screen (HTS) of thousands to millions of molecules to identify starting points for medicinal chemistry. Conventional HTS platforms require expensive reagents and typically...
3.
Kozole J, Levine L, Tomlinson-Phillips J, Stairs J
Talanta . 2015 Jun; 140:10-19. PMID: 26048817
The gas phase ion chemistry for an ion mobility spectrometer (IMS) based explosive detector has been elucidated using tandem mass spectrometry. The IMS system, which is operated with hexachloroethane and...
4.
Tomlinson-Phillips J, Wooten A, Kozole J, DeLine J, Beresford P, Stairs J
Talanta . 2014 Jun; 127:152-62. PMID: 24913870
Identification of the fragment ion species associated with the ion reaction mechanism of triacetone triperoxide (TATP), a homemade peroxide-based explosive, is presented. Ion mobility spectrometry (IMS) has proven to be...
5.
Kozole J, Tomlinson-Phillips J, Stairs J, Harper J, Lukow S, Lareau R, et al.
Talanta . 2012 Sep; 99:799-810. PMID: 22967626
A commercial-off-the-shelf (COTS) ion trap mobility spectrometry (ITMS) based explosive trace detector (ETD) has been interfaced to a triple quadrupole mass spectrometer (MS/MS) for the purpose of characterizing the gas...
6.
Kozole J, Stairs J, Cho I, Harper J, Lukow S, Lareau R, et al.
Anal Chem . 2011 Oct; 83(22):8596-603. PMID: 22017332
Hardware from a commercial-off-the-shelf (COTS) ion mobility spectrometry (IMS) based explosive trace detector (ETD) has been interfaced to an AB/SCIEX API 2000 triple quadrupole mass spectrometer. To interface the COTS...
7.
Kozole J, Willingham D, Winograd N
Appl Surf Sci . 2009 Jun; 255(14):1068-1070. PMID: 19554201
The effect of incident angle on the quality of SIMS molecular depth profiling using C(60) (+) was investigated. Cholesterol films of ~300 nm thickness on Si were employed as a...
8.
Kurczy M, Kozole J, Parry S, Piehowski P, Winograd N, Ewing A
Appl Surf Sci . 2009 Feb; 255(4):1158-1161. PMID: 19247454
We report the use of SIMS imaging to quantify the relative difference in the amount of lipid between two sections, the plasma membrane and the cytoplasm, of single cells from...
9.
Carado A, Passarelli M, Kozole J, Wingate J, Winograd N, Loboda A
Anal Chem . 2008 Oct; 80(21):7921-9. PMID: 18844371
A hybrid quadrupole orthogonal time-of-flight mass spectrometer optimized for matrix-assisted laser desorption ionization (MALDI) and electrospray ionization has been equipped with a C 60 cluster ion source. This configuration is...
10.
Kozole J, Wucher A, Winograd N
Anal Chem . 2008 Jun; 80(14):5293-301. PMID: 18549239
The role of the location of energy deposition during cluster ion bombardment on the quality of molecular depth profiling was examined by varying the incident angle geometry. Cholesterol films approximately...