Joseph J Baldassare
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Explore the profile of Joseph J Baldassare including associated specialties, affiliations and a list of published articles.
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24
Citations
252
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Recent Articles
1.
Quan T, Shao Y, Purohit T, Jiang Y, Qin Z, Fisher G, et al.
J Cell Commun Signal
. 2025 Feb;
19(1):e70003.
PMID: 39898007
CCN2 is widely regarded as a profibrotic factor involved in fibrotic disorders by regulating extracellular matrix (ECM). We report here that CCN2 functions as a critical cell cycle regulator in...
2.
Bowman T, Wong M, Cox L, Baldassare J, Chrivia J
Int J Cell Biol
. 2011 Jul;
2011:715642.
PMID: 21785598
The p400 and SRCAP (Snf2-related CBP activator protein) complexes remodel chromatin by catalyzing deposition of histone H2A.Z into nucleosomes. This remodeling activity has been proposed as a basis for regulation...
3.
Lunn C, Chrivia J, Baldassare J
Cell Cycle
. 2010 Nov;
9(22):4533-41.
PMID: 21088490
Cyclin E-associated CDK2 activity is required for the initiation of DNA synthesis in human cells. CDK2 activity is tightly regulated; CDK2 must be in the nucleus, bound to a cyclin,...
4.
Freudenburg W, Moran J, Lents N, Baldassare J, Buller R, Corbett J
J Innate Immun
. 2010 Apr;
2(1):77-86.
PMID: 20375625
Virus infection of macrophages stimulates the expression of proinflammatory and antiviral genes interleukin-1 (IL-1), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). In this study, we show that phosphatidylinositol 3-kinase...
5.
Xu Y, Baker D, Quan T, Baldassare J, Voorhees J, Fisher G
Mol Biol Cell
. 2009 Oct;
21(1):29-35.
PMID: 19864455
Epidermal growth factor receptor (EGFR) signaling pathways promote human keratinocyte survival and proliferation. In contrast, transforming growth factor-beta (TGF-beta) signaling pathways are strongly anti-proliferative. Receptor type protein tyrosine phosphatase-kappa (RPTP-kappa)...
6.
Lents N, Irintcheva V, Goel R, Wheeler L, Baldassare J
Cell Signal
. 2009 Mar;
21(6):1007-14.
PMID: 19250965
alpha-thrombin is a potent mitogen for fibroblasts and initiates a rapid signal transduction pathway leading to the activation of Ras and the stimulation of cell cycle progression. While the signaling...
7.
Gorges L, Lents N, Baldassare J
Am J Physiol Cell Physiol
. 2008 Sep;
295(5):C1151-60.
PMID: 18768921
The retinoblastoma protein pRb plays a pivotal role in G(1)- to S-phase cell cycle progression and is among the most frequently mutated gene products in human cancer. Although much focus...
8.
Wheeler L, Lents N, Baldassare J
Cell Cycle
. 2008 Jul;
7(14):2179-88.
PMID: 18635963
Progression through the mammalian cell division cycle is regulated by the sequential activation of cyclin-dependent kinases, CDKs, at specific phases of the cell cycle. Cyclin A-CDK2 and cyclin A-CDK1 phosphorylate...
9.
Lents N, Wheeler L, Baldassare J, Dynlacht B
Cell Cycle
. 2008 May;
7(11):1580-6.
PMID: 18469520
Mdm2, as the most important negative regulator of p53, plays an important homeostatic role in regulating cell division and the cellular response to DNA damage, oncogenic insult and other forms...
10.
Klein C, Creach K, Irintcheva V, Hughes K, Blackwell P, Corbett J, et al.
Apoptosis
. 2006 Oct;
11(11):1933-44.
PMID: 17013754
The effect of Zn on p53-independent cell death was examined in IIC9 embryonic fibroblasts. Despite the fact that these cells are p53-minus, Zn-mediated death occurs via an apoptotic mechanism. Death...