Joseph Holoshitz
Overview
Explore the profile of Joseph Holoshitz including associated specialties, affiliations and a list of published articles.
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34
Citations
664
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Recent Articles
1.
Scavuzzi B, van Drongelen V, Kaur B, Fox J, Liu J, Mesquita-Ferrari R, et al.
Commun Biol
. 2022 Jul;
5(1):751.
PMID: 35902632
The HLA-DRB1*03:01 allele is a major genetic risk factor in systemic lupus erythematosus (SLE), but the mechanistic basis of the association is unclear. Here we show that in the presence...
2.
Scavuzzi B, Holoshitz J
Antioxidants (Basel)
. 2022 Jul;
11(7).
PMID: 35883795
Background: The endoplasmic reticulum (ER) is a multi-functional organelle responsible for cellular homeostasis, protein synthesis, folding and secretion. It has been increasingly recognized that the loss of ER homeostasis plays...
3.
Scavuzzi B, van Drongelen V, Holoshitz J
Front Immunol
. 2022 Mar;
13:814967.
PMID: 35281038
Human leukocyte antigens (HLA) are significant genetic risk factors in a long list of diseases. However, the mechanisms underlying these associations remain elusive in many cases. The best-characterized function of...
4.
van Drongelen V, Scavuzzi B, Holoshitz J
Rheumatology (Oxford)
. 2021 Aug;
61(3):889-891.
PMID: 34436565
No abstract available.
5.
Kim J, Chun K, McGowan J, Zhang Y, Czernik P, Mell B, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(34).
PMID: 34408018
Inflammatory arthritis (IA) is a common disease that affects millions of individuals worldwide. Proinflammatory events during IA pathogenesis are well studied; however, loss of protective immunity remains underexplored. Earlier, we...
6.
van Drongelen V, Scavuzzi B, Nogueira S, Miller F, Sawalha A, Holoshitz J
Sci Rep
. 2021 Jan;
11(1):2599.
PMID: 33510427
Associations between particular human leukocyte antigen (HLA) alleles and susceptibility to-or protection from-autoimmune diseases have been long observed. Allele-specific antigen presentation (AP) has been widely proposed as a culprit, but...
7.
van Drongelen V, Ali W, Holoshitz J
J Immunol
. 2020 Jun;
205(3):579-586.
PMID: 32591395
Rheumatoid arthritis (RA) is closely associated with shared epitope (SE)-coding alleles and circulating anticitrullinated protein Abs (ACPA), but neither the respective pathogenic roles of SE and ACPA in RA nor...
8.
Fu J, Nogueira S, van Drongelen V, Coit P, Ling S, Rosloniec E, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(18):4755-4760.
PMID: 29666259
The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino acid sequence motif encoded by RA-associated alleles, is...
9.
Blanco L, Plegue M, Fung-Leung W, Holoshitz J
J Immune Based Ther Vaccines Antimicrob
. 2017 Jul;
2(3):29-38.
PMID: 28748127
Susceptibility to rheumatoid arthritis (RA) is associated with alleles coding a 5-amino acid sequence motif called the shared epitope (SE). To explore the potential mechanisms that lead to RA susceptibility,...
10.
van Drongelen V, Holoshitz J
Rheum Dis Clin North Am
. 2017 Jul;
43(3):363-376.
PMID: 28711139
The cause and pathogenesis of rheumatoid arthritis (RA) are influenced by environmental and genetic risk factors. Shared epitope-coding human leukocyte antigen (HLA)-DRB1 alleles increase RA risk and severity; however, the...