Joseph Giorgio
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Explore the profile of Joseph Giorgio including associated specialties, affiliations and a list of published articles.
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16
Citations
104
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Recent Articles
1.
Giorgio J, Soleimani-Meigooni D, Janabi M, Baker S, Chen X, Toueg T, et al.
J Nucl Med
. 2025 Mar;
PMID: 40049743
Synaptic density imaging with PET is a relatively new approach to monitoring synaptic injury in neurodegenerative diseases. However, there are remaining technical and clinical questions, including questions on reference region...
2.
Pezzoli S, Giorgio J, Chen X, Ward T, Harrison T, Jagust W
Alzheimers Dement
. 2025 Jan;
21(2):e14515.
PMID: 39807642
Introduction: Successful cognitive aging is related to both maintaining brain structure and avoiding Alzheimer's disease (AD) pathology, but how these factors interplay is unclear. Methods: A total of 109 cognitively...
3.
Lee L, Vaghari D, Burkhart M, Tino P, Montagnese M, Li Z, et al.
EClinicalMedicine
. 2025 Jan;
74:102725.
PMID: 39764178
Background: Predicting dementia early has major implications for clinical management and patient outcomes. Yet, we still lack sensitive tools for stratifying patients early, resulting in patients being undiagnosed or wrongly...
4.
Ziontz J, Harrison T, Fonseca C, Giorgio J, Han F, Lee J, et al.
Hum Brain Mapp
. 2024 Dec;
45(17):e70083.
PMID: 39651679
Tau pathology spread into neocortex indicates a transition from healthy aging to Alzheimer's disease (AD). Connectivity between tau epicenters and later accumulating regions of cortex has been proposed as a...
5.
Borne L, Thienel R, Lupton M, Guo C, Mosley P, Behler A, et al.
Sci Rep
. 2024 Nov;
14(1):27207.
PMID: 39516511
Deficits in memory are seen as a canonical sign of aging and a prodrome to dementia in older adults. However, our understanding of age-related cognition and brain morphology occurring throughout...
6.
Faucher C, Borne L, Behler A, Paton B, Giorgio J, Fripp J, et al.
Sleep Adv
. 2024 Sep;
5(1):zpae058.
PMID: 39221446
Study Objectives: Evidence suggests that poor sleep impacts cognition, brain health, and dementia risk but the nature of the association is poorly understood. This study examined how self-reported sleep duration,...
7.
Giorgio J, Jonson C, Wang Y, Yokoyama J, Wang J, Jagust W
Res Sq
. 2024 Aug;
PMID: 39149503
The canonical AD pathological cascade posits that the accumulation of amyloid beta ( ) is the initiating event, accelerating the accumulation of tau in the entorhinal cortex (EC), which subsequently...
8.
Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition
Ziontz J, Harrison T, Chen X, Giorgio J, Adams J, Wang Z, et al.
Cereb Cortex
. 2024 Apr;
34(4).
PMID: 38602736
Tau pathology is associated with cognitive impairment in both aging and Alzheimer's disease, but the functional and structural bases of this relationship remain unclear. We hypothesized that the integrity of...
9.
Giorgio J, Adams J, Maass A, Jagust W, Breakspear M
Neuron
. 2023 Dec;
112(4):676-686.e4.
PMID: 38096815
In early Alzheimer's disease (AD) β-amyloid (Aβ) deposits throughout association cortex and tau appears in the entorhinal cortex (EC). Why these initially appear in disparate locations is not understood. Using...
10.
Pezzoli S, Giorgio J, Martersteck A, Dobyns L, Harrison T, Jagust W
Alzheimers Dement
. 2023 Aug;
20(1):341-355.
PMID: 37614157
Introduction: There is no consensus on either the definition of successful cognitive aging (SA) or the underlying neural mechanisms. Methods: We examined the agreement between new and existing definitions using:...