Joseph D Ferrari
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Explore the profile of Joseph D Ferrari including associated specialties, affiliations and a list of published articles.
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10
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605
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Recent Articles
1.
Kenney L, Chiu R, Dutra M, Wactor A, Honan C, Shelerud L, et al.
Cell Rep Med
. 2024 Sep;
5(9):101717.
PMID: 39243754
Indoleamine-2,3-dioxygenase (IDO)1 degrades tryptophan, obtained through dietary intake, into immunoregulatory metabolites of the kynurenine pathway. Deficiency or blockade of IDO1 results in the enhancement of autoimmune severity in rodent models...
2.
de Picciotto S, DeVita N, Hsiao C, Honan C, Tse S, Nguyen M, et al.
Nat Commun
. 2022 Jul;
13(1):3866.
PMID: 35790728
Interleukin-2 (IL-2) is critical for regulatory T cell (Treg) function and homeostasis. At low doses, IL-2 can suppress immune pathologies by expanding Tregs that constitutively express the high affinity IL-2Rα...
3.
LaMothe R, Kolte P, Vo T, Ferrari J, Gelsinger T, Wong J, et al.
Front Immunol
. 2018 Mar;
9:281.
PMID: 29552007
T cells reacting to self-components can promote tissue damage when escaping tolerogenic control mechanisms which may result in autoimmune disease. The current treatments for these disorders are not antigen (Ag)...
4.
Kishimoto T, Ferrari J, LaMothe R, Kolte P, Griset A, ONeil C, et al.
Nat Nanotechnol
. 2016 Aug;
11(10):890-899.
PMID: 27479756
The development of antidrug antibodies (ADAs) is a common cause for the failure of biotherapeutic treatments and adverse hypersensitivity reactions. Here we demonstrate that poly(lactic-co-glycolic acid) (PLGA) nanoparticles carrying rapamycin,...
5.
Maldonado R, LaMothe R, Ferrari J, Zhang A, Rossi R, Kolte P, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
112(2):E156-65.
PMID: 25548186
Current treatments to control pathological or unwanted immune responses often use broadly immunosuppressive drugs. New approaches to induce antigen-specific immunological tolerance that control both cellular and humoral immune responses are...
6.
Yamamoto K, Ahyi A, Pepper-Cunningham Z, Ferrari J, Wilson A, Jones M, et al.
Am J Respir Cell Mol Biol
. 2013 Sep;
50(2):253-62.
PMID: 24010952
Epithelial cells line the respiratory tract and interface with the external world. Epithelial cells contribute to pulmonary inflammation, but specific epithelial roles have proven difficult to define. To discover unique...
7.
Ahyi A, Quinton L, Jones M, Ferrari J, Pepper-Cunningham Z, Mella J, et al.
Infect Immun
. 2013 Mar;
81(5):1644-53.
PMID: 23460517
The acute-phase response is characteristic of perhaps all infections, including bacterial pneumonia. In conjunction with the acute-phase response, additional biological pathways are induced in the liver and are dependent on...
8.
Jones M, Blahna M, Kozlowski E, Matsuura K, Ferrari J, Morris S, et al.
PLoS Genet
. 2012 Dec;
8(11):e1003105.
PMID: 23209448
The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem...
9.
Yamamoto K, Ferrari J, Cao Y, Ramirez M, Jones M, Quinton L, et al.
J Immunol
. 2012 Jul;
189(5):2450-9.
PMID: 22844121
Pneumonia results from bacteria in the alveoli. The alveolar epithelium consists of type II cells, which secrete surfactant and associated proteins, and type I cells, which constitute 95% of the...
10.
Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice
Quinton L, Blahna M, Jones M, Allen E, Ferrari J, Hilliard K, et al.
J Clin Invest
. 2012 Apr;
122(5):1758-63.
PMID: 22466650
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the...