Joseph C K Leung
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Explore the profile of Joseph C K Leung including associated specialties, affiliations and a list of published articles.
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93
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2011
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Recent Articles
11.
Wu H, Yiu W, Wong D, Li R, Chan L, Leung J, et al.
Oncotarget
. 2017 Dec;
8(61):103640-103656.
PMID: 29262590
Human induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) are emerging as attractive options for use in cell replacement therapy, but their effect in kidney diseases remains unknown. Here, we...
12.
Lai K, Leung J, Tang S
Kidney Dis (Basel)
. 2016 Aug;
1(1):19-26.
PMID: 27536661
Background: IgA nephropathy (IgAN) is a very common glomerulonephritis worldwide. Nevertheless, treatment options for primary IgAN are still largely based on opinion or weak evidence. There is a lack of...
13.
Lai K, Leung J, Tang S
F1000Res
. 2016 Feb;
5.
PMID: 26918170
Since its first description in 1968, IgA nephropathy has remained the most common form of primary glomerulonephritis leading to chronic kidney disease in developed countries. The clinical progression varies, and...
14.
Serino G, Pesce F, Sallustio F, De Palma G, Cox S, Curci C, et al.
Kidney Int
. 2015 Nov;
89(3):683-92.
PMID: 26581012
Immunoglobulin A nephropathy (IgAN) is a worldwide disease characterized by the presence of galactose-deficient IgA1 deposits in the glomerular mesangium. A kidney biopsy for diagnosis is required. Here, we measured...
15.
Yiu W, Wong D, Wu H, Li R, Yam I, Chan L, et al.
Kidney Int
. 2015 Nov;
89(2):386-98.
PMID: 26536000
Kallistatin is a serine protease inhibitor with anti-inflammatory, anti-angiogenic, and anti-oxidative properties. Since oxidative stress plays a critical role in the pathogenesis of diabetic nephropathy, we studied the effect and...
16.
Liu R, Hu B, Li Q, Jing X, Zhong C, Chang Y, et al.
Gene
. 2015 Jun;
571(1):43-51.
PMID: 26095808
Background: Previously, a large proportion of the genetic components predisposing individuals to IgA nephropathy (IgAN) have been unidentified. Familial IgAN is enriched with genetic variations predisposing individuals to the disease....
17.
Leung J, Chan L, Saleem M, Mathieson P, Tang S, Lai K
Apoptosis
. 2015 Mar;
20(7):907-20.
PMID: 25808596
Glomerulo-podocytic communication plays an important role in the podocytic injury in IgA nephropathy (IgAN). In this study, we examine the role of podocytic angiotensin II receptor subtype 1 (AT1R) and...
18.
Li R, Yiu W, Wu H, Wong D, Chan L, Lin M, et al.
Clin Sci (Lond)
. 2014 Sep;
128(4):269-80.
PMID: 25200314
Bone morphogenetic protein 7 (BMP7) has been reported to confer renoprotective effects in acute and chronic kidney disease models, but its potential role in Type 2 diabetic nephropathy remains unknown....
19.
Lim A, Chan L, Tang S, Lai K, Leung J
Inflamm Res
. 2014 Jul;
63(10):831-9.
PMID: 25063374
Objective: Kidney injury molecule-1 (KIM-1) serves as a useful marker for monitoring tubular injury, and sustained KIM-1 expression may be implicated in chronic kidney fibrosis. In this study, we examine...
20.
Wu H, Yiu W, Li R, Wong D, Leung J, Chan L, et al.
PLoS One
. 2014 Mar;
9(3):e90883.
PMID: 24646687
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have recently shown promise as a therapeutic tool in various types of chronic kidney disease (CKD) models. However, the mechanism of action is incompletely...