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Joseph B Dube

Explore the profile of Joseph B Dube including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 158
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Recent Articles
1.
Dube J, Lin T, Best S, Truemner J, Sargeant P, Borrie M
Alzheimers Dement (N Y) . 2019 Oct; 5:501-507. PMID: 31650006
Introduction: Innovative recruitment strategies are needed to better engage potential research participants at a preclinical stage of cognitive decline. Methods: Local newspaper advertisements attracted community-dwelling people ≥55 years with memory...
2.
Patel A, Peloso G, Pirruccello J, Johansen C, Dube J, Larach D, et al.
Atherosclerosis . 2016 May; 250:63-8. PMID: 27182959
Objective: Genome-wide association studies (GWAS) for plasma lipid levels have mapped numerous genomic loci, with each region often containing many protein-coding genes. Targeted re-sequencing of exons is a strategy to...
3.
Dube J, Wang J, Cao H, McIntyre A, Johansen C, Hopkins S, et al.
Circ Cardiovasc Genet . 2014 Nov; 8(1):100-5. PMID: 25414273
Background: Inuit are considered to be vulnerable to cardiovascular disease because their lifestyles are becoming more Westernized. During sequence analysis of Inuit individuals at extremes of lipid traits, we identified...
4.
Johansen C, Dube J, Loyzer M, Macdonald A, Carter D, McIntyre A, et al.
J Lipid Res . 2014 Feb; 55(4):765-72. PMID: 24503134
We report the design of a targeted resequencing panel for monogenic dyslipidemias, LipidSeq, for the purpose of replacing Sanger sequencing in the clinical detection of dyslipidemia-causing variants. We also evaluate...
5.
Fu J, Kwok S, Sinai L, Abdel-Razek O, Babula J, Chen D, et al.
Can J Cardiol . 2013 Apr; 29(8):934-9. PMID: 23623477
Background: Next-generation sequencing (NGS) is nearing routine clinical application, especially for diagnosis of rare monogenic cardiovascular diseases. But NGS uncovers so much variation in an individual genome that filtering steps...
6.
Dube J, Hegele R
Can J Cardiol . 2012 Dec; 29(1):10-7. PMID: 23200095
The spring of 2012 marked the fifth anniversary of the widespread appearance in the biomedical literature of genome-wide association studies (GWAS) of diseases of adulthood. Articles reporting GWAS results now...
7.
Dube J, Johansen C, Robinson J, Lindsay J, Hachinski V, Hegele R
J Alzheimers Dis . 2012 Oct; 33(3):831-40. PMID: 23042215
Dementia is a heritable condition with devastating effects on both patients and their caregivers. Studies have identified genetic variants associated with increased susceptibility to late-onset Alzheimer disease (AD)-related dementia; however,...
8.
Dube J, Boffa M, Hegele R, Koschinsky M
Curr Opin Lipidol . 2012 Feb; 23(2):133-40. PMID: 22327610
Purpose Of Review: Lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease; we highlight the most recent research initiatives that have sought to define Lp(a)-dependent pathogenicity as well as pharmacologic...
9.
Dube J, Johansen C, Hegele R
Bioessays . 2011 Apr; 33(6):430-7. PMID: 21462369
The concentration of low-density lipoprotein (LDL) cholesterol (C) in plasma is a key determinant of cardiovascular disease risk and human genetic studies have long endeavoured to elucidate the pathways that...